Technology Process of Piperidine,
1-[3,5-bis(trifluoromethyl)benzoyl]-4-[4-[1-[(5-methyl-4-isoxazolyl)carbon
yl]-4-piperidinyl]-1-piperazinyl]-2-(phenylmethyl)-, (2R,4S)-
There total 11 articles about Piperidine,
1-[3,5-bis(trifluoromethyl)benzoyl]-4-[4-[1-[(5-methyl-4-isoxazolyl)carbon
yl]-4-piperidinyl]-1-piperazinyl]-2-(phenylmethyl)-, (2R,4S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-methyl-1,2-oxazole-4-carboxylic acid;
With
1,1'-carbonyldiimidazole;
In
dichloromethane;
at 20 ℃;
for 2h;
C30H36F6N4O;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: toluene / 20 °C
2.1: ethanol; water / 20 h / 60 °C
3.1: pyrographite / 2 h / 40 °C
3.2: 20 - 50 °C
4.1: hydrogen / palladium 10% on activated carbon
5.1: thiophene; hydrogen / palladium 10% on activated carbon / methanol / 50 °C
6.1: hydrogen / palladium 10% on activated carbon / methanol
7.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C
With
thiophene; hydrogen; pyrographite; 1,1'-carbonyldiimidazole;
palladium 10% on activated carbon;
In
methanol; ethanol; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: thiophene; hydrogen / palladium 10% on activated carbon / methanol / 50 °C
2: hydrogen / palladium 10% on activated carbon / methanol
3: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C
With
thiophene; hydrogen; 1,1'-carbonyldiimidazole;
palladium 10% on activated carbon;
In
methanol; dichloromethane;
