681291-92-9

Basic information

• Product Name: Piperidine, 1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-(1-piperazinyl)-, (2R,4S)-
• CAS NO: 681291-92-9
• Molecular Formula: C25H27F6N3O
• Molecular Weight: 499.499
• Mol File: 681291-92-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-(1-piperazinyl)-, (2R,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-(1-piperazinyl)-, (2R,4S)-(681291-92-9)
• EPA Substance Registry System: Piperidine, 1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-(1-piperazinyl)-, (2R,4S)-(681291-92-9)

Safety Data

• Hazardous Substances Data: 681291-92-9(Hazardous Substances Data)

Upstream product

• 717927-37-2 (+)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinone 
• 681291-90-7 C₂₃H₂₁F₆NO₃ 
• 193201-63-7 (±)-7-(phenylmethyl)-1,4-dioxa-8-azaspiro[4.5]decane 
• 785-56-8 3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride 
• 123387-51-9 tert-butyl 1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate 
• 100-52-7 benzaldehyde 
• 681291-91-8 (+)-(2R-trans)-1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-[4-(phenylmethyl)-1-piperazinyl]piperidine 

Downstream Products

• 815579-76-1 C₂₉H₃₈N₈O₂S₂ 
• 681290-30-2 C₃₀H₃₆F₆N₄O 
• 681290-40-4 C₃₄H₃₈F₆N₆O₂ 
• 681290-33-5 C₃₅H₃₈F₆N₄O₂S 
• 681290-31-3 C₃₇H₄₀F₆N₄O₂ 
• 681290-37-9 C₃₆H₄₃F₆N₅O 
• 681290-32-4 C₃₅H₃₉F₆N₅O₃ 
• 681291-42-9 C₃₆H₄₂F₆N₄O₂S 
• 681290-36-8 C₃₇H₄₃F₆N₅O₂ 
• 681291-56-5 C₃₄H₃₈F₆N₆O₃S 
• 681290-35-7 C₃₈H₄₂F₆N₆O 
• 681290-34-6 C₄₂H₄₉F₆N₅O₃ 
• 681291-95-2 C₂₁H₃₄N₄ 

Relevant articles and documents

Process development of the synthetic route to R116301

We describe in this paper the synthesis of compound 1 (R116301), which was developed to prepare pilot scale quantities (20-50 kg) of drug substance. The synthesis involves the sBuLi deprotonation of Boc-protected piperidone acetal 2, followed b

SUBSTITUTED 4-(4-PIPERIDIN-4-YL-PIPERAZIN-1-YL)-AZEPANE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS

The invention concerns substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives having neurokinin antagonistic activity, in particular NK1 antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in pa

SUBSTITUTED 1-PIPERIDIN-4-YL-4-AZETIDIN-3-YL-PIPERAZINE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS

The invention concerns substituted 1-piperidin-4-yl-4-azefdin-3-yl-piperazine having neurokinin antagonistic activity, in particular NK1 and NK1/NK3- antagonistic activity, their preparation, compositions comprising them and their use as a medicine, in pa