1-(2-Phenylethyl)-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 1-(2-Phenylethyl)-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 68263-23-0
• Molecular Formula: C17H19N
• Molecular Weight: 237.345
• DSSTox Substance ID: DTXSID70508684
• Nikkaji Number: J1.597.929A
• Mol file: 68263-23-0.mol

Synonyms:68263-23-0;1-(2-phenylethyl)-1,2,3,4-tetrahydroisoquinoline;1-Phenethyl-1,2,3,4-tetrahydroisoquinoline;Isoquinoline, 1,2,3,4-tetrahydro-1-(2-phenylethyl)-;phenethyltetrahydroisoquinoline;DTXSID70508684;MFCD09886755;AKOS013354157;NS-03250;1-phenethyl-1,2,3,4-tetrahydro-isoquinoline

Chemical Property of 1-(2-Phenylethyl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 237.151749610
• Heavy Atom Count: 18
• Complexity: 244

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNC(C2=CC=CC=C21)CCC3=CC=CC=C3

Technology Process of 1-(2-Phenylethyl)-1,2,3,4-tetrahydroisoquinoline

There total 22 articles about 1-(2-Phenylethyl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-phenethyl-3,4-dihydroisoquinoline (93816-58-1) → 1,2,3,4-tetrahydro-1-(2-phenetyl)isoquinoline (68263-23-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 25 ℃; for 1h;

DOI:10.1039/d0cc01969k

Reference yield: 96.0%

C22H19N → 1,2,3,4-tetrahydro-1-(2-phenetyl)isoquinoline (68263-23-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 25 ℃; for 1h;

DOI:10.1039/d0cc01969k

Reference yield: 93.0%

benzyl 1-(2-oxo-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate (1428485-05-5) → 1,2,3,4-tetrahydro-1-(2-phenetyl)isoquinoline (68263-23-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; acetic acid; trifluoroacetic acid; In water; at 20 ℃; for 5h;

DOI:10.1016/j.tetlet.2014.03.094

upstream raw materials:

tert-Butyl-[1-(1-phenethyl-3,4-dihydro-1H-isoquinolin-2-yl)-meth-(E)-ylidene]-amine

1,2,3,4-tetrahydroisoquinoline

tert-Butyl-[1-(3,4-dihydro-1H-isoquinolin-2-yl)-meth-(E)-ylidene]-amine

benzyl 1-(2-oxo-2-phenylethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate