Piperidine, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-bis(phenylmethoxy)-5 -[(phenylmethoxy)methyl]-1-(phenylmethyl)-, (2R,3R,4R,5R)-

Base Information

Chemical Name:Piperidine, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-bis(phenylmethoxy)-5 -[(phenylmethoxy)methyl]-1-(phenylmethyl)-, (2R,3R,4R,5R)-
CAS No.:682771-66-0
Molecular Formula:C41H53NO4Si
Molecular Weight:651.962
Hs Code.:

Piperidine,
2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-bis(phenylmethoxy)-5
-[(phenylmethoxy)methyl]-1-(phenylmethyl)-, (2R,3R,4R,5R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Piperidine, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-bis(phenylmethoxy)-5 -[(phenylmethoxy)methyl]-1-(phenylmethyl)-, (2R,3R,4R,5R)-

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Technology Process of Piperidine, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-bis(phenylmethoxy)-5 -[(phenylmethoxy)methyl]-1-(phenylmethyl)-, (2R,3R,4R,5R)-

There total 3 articles about Piperidine, 2-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-3,4-bis(phenylmethoxy)-5 -[(phenylmethoxy)methyl]-1-(phenylmethyl)-, (2R,3R,4R,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 682771-65-9
3,4-di-O-benzyl-2-C-benzyloxymethyl-6-O-tert-butyldimethylsilyl-1,2,5-trideoxy-1,5-imino-D-glucitol

: 100-39-0
benzyl bromide

: 682771-66-0
N-benzyl-3,4-di-O-benzyl-2-C-benzyloxymethyl-6-O-tert-butyldimethylsilyl-1,2,5-trideoxy-1,5-imino-D-glucitol

Guidance literature:: With triethylamine; In acetonitrile; for 16h;
DOI:10.1016/j.bmc.2003.12.040

Reference yield:

: 682771-59-1
3,4-di-O-benzyl-2-C-benzyloxymethyl-6-O-tert-butyldimethylsilyl-2-deoxy-D-gluco-δ-lactam

: 682771-66-0
N-benzyl-3,4-di-O-benzyl-2-C-benzyloxymethyl-6-O-tert-butyldimethylsilyl-1,2,5-trideoxy-1,5-imino-D-glucitol

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / BH₃*Me₂S / CH₂Cl₂ / 16 h / 20 °C

2: 49 percent / Et₃N / acetonitrile / 16 h

With dimethylsulfide borane complex; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2003.12.040

Reference yield:

: (3R,4R,5S)-4,5-Bis-benzyloxy-3-benzyloxymethyl-6-(tert-butyl-dimethyl-silanyloxymethyl)-6-hydroxy-piperidin-2-one

: 682771-66-0
N-benzyl-3,4-di-O-benzyl-2-C-benzyloxymethyl-6-O-tert-butyldimethylsilyl-1,2,5-trideoxy-1,5-imino-D-glucitol

Guidance literature:: Multi-step reaction with 3 steps

1: 63 percent / NaCNBH₃; formic acid / acetonitrile / 2 h / Heating

2: 61 percent / BH₃*Me₂S / CH₂Cl₂ / 16 h / 20 °C

3: 49 percent / Et₃N / acetonitrile / 16 h

With formic acid; dimethylsulfide borane complex; sodium cyanoborohydride; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmc.2003.12.040