3-hydroxy-N-methylpropanamide

Base Information

• Chemical Name: 3-hydroxy-N-methylpropanamide
• CAS No.: 6830-81-5
• Molecular Formula: C4H9NO2
• Molecular Weight: 103.121
• Hs Code.: 2924199090
• European Community (EC) Number: 800-721-8
• DSSTox Substance ID: DTXSID00574211
• Wikidata: Q82463177
• Mol file: 6830-81-5.mol

Synonyms:3-hydroxy-N-methylpropanamide;6830-81-5;MFCD13188569;Propanamide, 3-hydroxy-N-methyl-;SCHEMBL146293;N-methyl-3-hydroxyl-propionamide;DTXSID00574211;AC6610;AKOS005174208;LS-04191;SY083761;3-hydroxy-N-Methylpropanamide, AldrichCPR;CS-0188403;EN300-74513;3-hydroxy-N-methylpropanamide(SALTDATA: FREE);Z975909370

Chemical Property of 3-hydroxy-N-methylpropanamide

Chemical Property:

• Boiling Point: 131-135 °C(Press: 3 Torr)
• PKA: 14.23±0.10(Predicted)
• PSA: 49.33000
• Density: 1.052±0.06 g/cm3(Predicted)
• LogP: -0.49430
• Storage Temp.: 2-8°C
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 103.063328530
• Heavy Atom Count: 7
• Complexity: 62.7

Purity/Quality:

98%min ^*data from raw suppliers

3-hydroxy-N-methylpropanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC(=O)CCO

Technology Process of 3-hydroxy-N-methylpropanamide

There total 1 articles about 3-hydroxy-N-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

NSC 677915 (99324-92-2) → 3-hydroxyl-N-methylpropanamide (6830-81-5) + ethene (74-85-1)

Guidance literature:

With lithium hypochlorite; In water; Ambient temperature;

DOI:10.1021/jo00269a014

Reference yield: 75.0%

3-hydroxyl-N-methylpropanamide (6830-81-5) + DL-N-(t-butoxycarbonyl)-2-phenyl-β-alanine (67098-56-0,181140-88-5,136916-26-2) → 3-(methylamino)-3-oxopropyl 3-((tert-butoxycarbonyl)amino)-2-phenylpropanoate

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;

Reference yield:

3-hydroxyl-N-methylpropanamide (6830-81-5) → N-methylacrylamide (1187-59-3,25722-14-9)

Guidance literature:

With aluminium oxide thorium oxide-catalyst; at 290 - 320 ℃; under 2 Torr;

upstream raw materials:

NSC 677915

Downstream raw materials:

N-methylacrylamide

2-benzyl-3-methyl-[1,3]oxazinan-4-one

3-methyl-2-phenyl-1,3-oxazinan-4-one

2,3-dimethyl-2-phenyl-[1,3]oxazinan-4-one