2,5-anhydro-1-deoxy-1-phosphonoaltritol

Base Information

• Chemical Name: 2,5-anhydro-1-deoxy-1-phosphonoaltritol
• CAS No.: 86762-89-2
• Molecular Formula: C₆H₁₃O₇P
• Molecular Weight: 228.139
• Mol file: 86762-89-2.mol

Synonyms:Ribose-1-methylenephosphonate

Chemical Property of 2,5-anhydro-1-deoxy-1-phosphonoaltritol

Chemical Property:

• Vapor Pressure: 3.68E-16mmHg at 25°C
• Boiling Point: 585.8°C at 760 mmHg
• Flash Point: 308.1°C
• PSA: 137.26000
• Density: 1.721g/cm³
• LogP: -2.35440

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-anhydro-1-deoxy-1-phosphonoaltritol

There total 4 articles about 2,5-anhydro-1-deoxy-1-phosphonoaltritol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C34H47O7PSi2 → 2,5-anhydro-1-deoxy-1-phosphono-D-altritol (86762-89-2)

Guidance literature:

With trifluoroacetic acid; In chloroform-d1; for 0.5h;

DOI:10.1021/jm00374a028

Reference yield:

2,3-O-isopropylidene-5-O-trityl-D-ribofuranose (54503-64-9,54503-65-0) → 2,5-anhydro-1-deoxy-1-phosphono-D-altritol (86762-89-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 50percent aq. NaOH / CH₂Cl₂ / 18 h

2: CDCl₃ / 0.33 h

3: aq. TFA / CDCl₃ / 0.5 h

With sodium hydroxide; trifluoroacetic acid; In chloroform-d1; dichloromethane;

DOI:10.1021/jm00374a028

Reference yield:

D-altro-2,5-anhydro-1-deoxy-1-(dimethoxyphosphinyl)-3,4-O-isopropylidene-6-O-tritylhexitol (90481-99-5) → 2,5-anhydro-1-deoxy-1-phosphono-D-altritol (86762-89-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CDCl₃ / 0.33 h

2: aq. TFA / CDCl₃ / 0.5 h

With trifluoroacetic acid; In chloroform-d1;

DOI:10.1021/jm00374a028

upstream raw materials:

2,3-O-isopropylidene-5-O-trityl-D-ribofuranose

D-altro-2,5-anhydro-1-deoxy-1-(dimethoxyphosphinyl)-3,4-O-isopropylidene-6-O-tritylhexitol

D-altro-2,5-anhydro-1-deoxy-1-(dimethoxyphosphinyl)-3,4-O-isopropylidenehexitol