D-altro-2,5-anhydro-1-deoxy-1-(dimethoxyphosphinyl)-3,4-O-isopropylidene-6-O-tritylhexitol

Base Information

• Chemical Name: D-altro-2,5-anhydro-1-deoxy-1-(dimethoxyphosphinyl)-3,4-O-isopropylidene-6-O-tritylhexitol
• CAS No.: 90481-99-5
• Molecular Formula: C₃₀H₃₅O₇P
• Molecular Weight: 538.577
• Mol file: 90481-99-5.mol

Synonyms:D-altro-2,5-anhydro-1-deoxy-1-(dimethoxyphosphinyl)-3,4-O-isopropylidene-6-O-tritylhexitol

Chemical Property of D-altro-2,5-anhydro-1-deoxy-1-(dimethoxyphosphinyl)-3,4-O-isopropylidene-6-O-tritylhexitol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of D-altro-2,5-anhydro-1-deoxy-1-(dimethoxyphosphinyl)-3,4-O-isopropylidene-6-O-tritylhexitol

There total 1 articles about D-altro-2,5-anhydro-1-deoxy-1-(dimethoxyphosphinyl)-3,4-O-isopropylidene-6-O-tritylhexitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.64%

tetramethyl methylenediphosphonate (16001-93-7) + 2,3-O-isopropylidene-5-O-trityl-D-ribofuranose (54503-64-9,54503-65-0) → D-altro-2,5-anhydro-1-deoxy-1-(dimethoxyphosphinyl)-3,4-O-isopropylidene-6-O-tritylhexitol (90481-99-5) + D-allo-2,5-anhydro-1-deoxy-1-(dimethoxyphosphinyl)-3,4-O-isopropylidene-6-O-tritylhexitol (90482-00-1)

Guidance literature:

With sodium hydroxide; In dichloromethane; water; at 20 ℃;

DOI:10.3762/bjoc.5.37

Reference yield:

trimethylsilyl bromide (2857-97-8) + D-altro-2,5-anhydro-1-deoxy-1-(dimethoxyphosphinyl)-3,4-O-isopropylidene-6-O-tritylhexitol (90481-99-5) → C34H47O7PSi2

Guidance literature:

In chloroform-d1; for 0.333333h;

DOI:10.1021/jm00374a028

Reference yield:

D-altro-2,5-anhydro-1-deoxy-1-(dimethoxyphosphinyl)-3,4-O-isopropylidene-6-O-tritylhexitol (90481-99-5) → 2,5-anhydro-1-deoxy-1-phosphono-D-altritol (86762-89-2)

Guidance literature:

Multi-step reaction with 2 steps

1: CDCl₃ / 0.33 h

2: aq. TFA / CDCl₃ / 0.5 h

With trifluoroacetic acid; In chloroform-d1;

DOI:10.1021/jm00374a028

upstream raw materials:

tetramethyl methylenediphosphonate

2,3-O-isopropylidene-5-O-trityl-D-ribofuranose

Downstream raw materials:

2,5-anhydro-1-deoxy-1-phosphono-D-altritol