Ribasine

Base Information

Chemical Name:Ribasine
CAS No.:87099-54-5
Deprecated CAS:1391-80-6,86702-41-2
Molecular Formula:C20H17NO5
Molecular Weight:351.35
Hs Code.:
Nikkaji Number:J342.451K
Wikidata:Q104396680

Synonyms:Ribasine;Grandiflorine;Limogine;Deoxyhimalayamine;(+)-Ribasine;NSC607979;NSC 607979;87099-54-5;( )-Ribasine;6H-6a,14-Epoxy-1,3-dioxolo(4,5-i)(1,3)dioxolo(5,6)indeno(2,1-c)(2)benzazepine, 12,12a,13,14-tetrahydro-13-methyl-, (6aS,12aR,14S)-;6H-6a,14-Epoxy-1,3-dioxolo(4,5-i)(1,3)dioxolo(5,6)indeno(2,1-c)(2)benzazepine, 12,12a,13,14-tetrahydro-13-methyl-, (6aS-(6aalpha,12abeta,14alpha))-;6H-6a,14-Epoxy-1,3-dioxolo[4,5-i][1,3]dioxolo[5,6]indeno [2,1-c][2]benzazepine, 12,12a,13,14-tetrahydro-13-methyl-, [6aS-(6a.alpha.,12a. beta.,14.alpha)]-;AKOS040751950

Suppliers and Price of Ribasine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of Ribasine

Chemical Property:

Vapor Pressure:1.48E-09mmHg at 25°C
Boiling Point:484.9°C at 760 mmHg
Flash Point:147.3°C
PSA：49.39000
Density:1.57g/cm³
LogP:2.41880
XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:0
Exact Mass:351.11067264
Heavy Atom Count:26
Complexity:617

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2CC3=CC4=C(C=C3C25CC6=C(C1O5)C7=C(C=C6)OCO7)OCO4
Isomeric SMILES:CN1[C@@H]2CC3=CC4=C(C=C3[C@@]25CC6=C([C@@H]1O5)C7=C(C=C6)OCO7)OCO4

Technology Process of Ribasine

There total 9 articles about Ribasine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 88151-42-2
dihydroribasine

: 87099-54-5
ribasine

Guidance literature:: With pyridine; sodium carbonate; Ambient temperature;
DOI:10.1016/S0040-4039(00)85932-8

Reference yield:

: 75267-22-0
ethyl 6-methyl-2,3-(methylenedioxy)benzoate

: 87099-54-5
ribasine

Guidance literature:: Multi-step reaction with 6 steps

1: 77 percent / N-bromosuccinimide / CCl₄ / 2 h / Heating; Irradiation

2: tellurium / tetrahydrofuran; hexane / 0.5 h / 0 °C

3: 90 percent / n-BuLi / tetrahydrofuran; hexane / 0.25 h / -105 °C

4: 95 percent / DIBAL-H / tetrahydrofuran; hexane / 2 h / -78 °C

5: 83 percent / TFA / CH₂Cl₂ / 5 h / 0 °C

6: 2.) NaBH₄ / 1.) MeOH, reflux, 1 h, 2.) room temperature, 5 h

With tellurium; sodium tetrahydroborate; N-Bromosuccinimide; n-butyllithium; diisobutylaluminium hydride; trifluoroacetic acid; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane;
DOI:10.1016/S0040-4020(99)00133-7

Reference yield:

: 197293-71-3
6-(bromomethyl)-2,3-(methylenedioxy)benzoic acid ethyl ester

: 87099-54-5
ribasine

Guidance literature:: Multi-step reaction with 5 steps

1: tellurium / tetrahydrofuran; hexane / 0.5 h / 0 °C

2: 90 percent / n-BuLi / tetrahydrofuran; hexane / 0.25 h / -105 °C

3: 95 percent / DIBAL-H / tetrahydrofuran; hexane / 2 h / -78 °C

4: 83 percent / TFA / CH₂Cl₂ / 5 h / 0 °C

5: 2.) NaBH₄ / 1.) MeOH, reflux, 1 h, 2.) room temperature, 5 h

With tellurium; sodium tetrahydroborate; n-butyllithium; diisobutylaluminium hydride; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/S0040-4020(99)00133-7