L-Alanine, N-[(2S)-2-[3-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-4H-1,2, 4-triazol-4-yl]-3-(4-methoxyphenyl)-1-oxopropyl]-, methyl ester

Base Information

Chemical Name:L-Alanine, N-[(2S)-2-[3-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-4H-1,2, 4-triazol-4-yl]-3-(4-methoxyphenyl)-1-oxopropyl]-, methyl ester
CAS No.:684233-22-5
Molecular Formula:C23H33N5O6
Molecular Weight:475.545
Hs Code.:

Synonyms:

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Chemical Property of L-Alanine, N-[(2S)-2-[3-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-4H-1,2, 4-triazol-4-yl]-3-(4-methoxyphenyl)-1-oxopropyl]-, methyl ester

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Technology Process of L-Alanine, N-[(2S)-2-[3-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-4H-1,2, 4-triazol-4-yl]-3-(4-methoxyphenyl)-1-oxopropyl]-, methyl ester

There total 1 articles about L-Alanine, N-[(2S)-2-[3-[(1S)-1-[[(1,1-dimethylethoxy)carbonyl]amino]ethyl]-4H-1,2, 4-triazol-4-yl]-3-(4-methoxyphenyl)-1-oxopropyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 624-84-0
formic acid hydrazide

: 684233-21-4
(S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-thiopropionylamino)-3-(4-methoxy-phenyl)-propionylamino]-propionic acid methyl ester

: 684233-22-5
(S)-2-[(S)-2-[3-((S)-1-tert-Butoxycarbonylamino-ethyl)-[1,2,4]triazol-4-yl]-3-(4-methoxy-phenyl)-propionylamino]-propionic acid methyl ester

Guidance literature:: formic acid hydrazide; (S)-2-[(S)-2-((S)-2-tert-Butoxycarbonylamino-thiopropionylamino)-3-(4-methoxy-phenyl)-propionylamino]-propionic acid methyl ester; With mercury(II) diacetate; In acetonitrile; at 20 ℃; for 0.333333h;

With 4 A molecular sieve; toluene-4-sulfonic acid; In chloroform; at 20 ℃; for 10h;
DOI:10.1021/ol040005r

Reference yield:

: 684233-22-5
(S)-2-[(S)-2-[3-((S)-1-tert-Butoxycarbonylamino-ethyl)-[1,2,4]triazol-4-yl]-3-(4-methoxy-phenyl)-propionylamino]-propionic acid methyl ester

: (S)-2-[(S)-2-[3-((S)-1-Amino-ethyl)-[1,2,4]triazol-4-yl]-3-(4-methoxy-phenyl)-propionylamino]-propionic acid methyl ester

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.5h;
DOI:10.1021/ol040005r

Reference yield:

: 684233-22-5
(S)-2-[(S)-2-[3-((S)-1-tert-Butoxycarbonylamino-ethyl)-[1,2,4]triazol-4-yl]-3-(4-methoxy-phenyl)-propionylamino]-propionic acid methyl ester

: C₄₁H₄₈N₈O₈

Guidance literature:: Multi-step reaction with 7 steps

1: aq. HCl / dioxane / 0.5 h / 20 °C

2: 67.2 mg / HOBt; Et₃N; EDC / CHCl₃ / 10 h / 20 °C

3: 95 percent / LiOH*H₂O / tetrahydrofuran; methanol; H₂O / 3 h / 20 °C

4: 50.3 mg / HOObt; EDC / tetrahydrofuran / 48 h / 20 °C

5: 94 percent / H₂ / Pd/C / ethanol / 1 h

6: aq. HCl / dioxane / 2 h / 20 °C

7: 2.4 mg / FDPP; (i-Pr)2NEt / dimethylformamide / 120 h / 0 - 20 °C

With hydrogenchloride; lithium hydroxide; pentafluorophenyl diphenyl-phosphinate; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/ol040005r