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624-84-0 Usage


Formylhydrazine, also known as formic acid hydrazide, is a white, shiny crystalline flake compound with significant chemical properties. It is a versatile chemical intermediate that plays a crucial role in the synthesis of various organic compounds.


Used in Pharmaceutical Industry:
Formylhydrazine is used as a precursor in the preparation of 1,2,4-triazole derivatives, which are important compounds in the pharmaceutical industry. These derivatives have a wide range of applications, including the development of new drugs and the modification of existing ones to improve their efficacy and safety.
Used in Anticancer Applications:
Formylhydrazine is also used in the synthesis of 6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosyl)-5H-indolo[2,3-a]-pyrrolo[3,4-c]carbazole-5,7(6H)-dione, which is an anticancer agent. Formylhydrazine has shown potential in the treatment of various types of cancer, making formylhydrazine a valuable component in the development of novel cancer therapies.

Purification Methods

Recrystallise it from EtOH and dry it in vacuo. Store below 10o; it may disproportionate on storage to 1,2-diformyl hydrazine and hydrazine. It forms a blue [Cu(CH4N2O)]SO4 salt with CuSO4. [Beilstein 2 H 93, 2 III 127, 2 IV 85.]

Check Digit Verification of cas no

The CAS Registry Mumber 624-84-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 4 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 624-84:
70 % 10 = 0
So 624-84-0 is a valid CAS Registry Number.

624-84-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Detail
  • Alfa Aesar

  • (A14901)  Formic acid hydrazide, 98%   

  • 624-84-0

  • 25g

  • 546.0CNY

  • Detail
  • Alfa Aesar

  • (A14901)  Formic acid hydrazide, 98%   

  • 624-84-0

  • 100g

  • 1714.0CNY

  • Detail
  • Aldrich

  • (166375)  Formichydrazide  

  • 624-84-0

  • 166375-25G

  • 597.87CNY

  • Detail
  • Aldrich

  • (166375)  Formichydrazide  

  • 624-84-0

  • 166375-100G

  • 1,843.92CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017


1.1 GHS Product identifier

Product name Formylhydrazine

1.2 Other means of identification

Product number -
Other names Hydrazinecarboxaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:624-84-0 SDS

624-84-0Relevant articles and documents



, p. 2638 (1968)


Heavy-atom isotope effects on the hydrazinolysis of methyl formate

Marlier, John F.,Haptonstall, Brandy A.,Johnson, Amanda J.,Sacksteder, Katherine A.

, p. 8838 - 8842 (1997)

The carbonyl carbon, carbonyl oxygen, and nitrogen nucleophile isotope effects were measured for the hydrazinolysis of methyl formate at pH 8 and 10. At pH 8, where breakdown of a tetrahedral intermediate to products is rate-determining, the carbonyl carbon isotope effect is k12/k13 = 1.038, the carbonyl oxygen isotope effect is k16/k18 = 1.003, and the nitrogen nucleophile isotope effect is k14/k15 = 0.990. The isotope effects at pH 8 are consistent with a late transition state, which greatly resembles the hydrazide product. At pH 10, where formation of a tetrahedral intermediate is rate-determining, the carbonyl carbon isotope effect is k12/k13 = 1.020, the carbonyl oxygen isotope effect is k16/k18 = 1.004, and the nitrogen nucleophile isotope effect is k14/k15 = 0.9917. These isotope effects are best rationalized in terms of a concerted general base catalyzed nucleophilic attack of hydrazine on methyl formate as the rate-determining step.

Design, synthesis, in vitro and in vivo evaluation against MRSA and molecular docking studies of novel pleuromutilin derivatives bearing 1, 3, 4-oxadiazole linker

Liu, Jie,Zhang, Guang-Yu,Zhang, Zhe,Li, Bo,Chai, Fei,Wang, Qi,Zhou, Zi-Dan,Xu, Ling-Ling,Wang, Shou-Kai,Jin, Zhen,Tang, You-Zhi

, (2021/05/17)

A class of pleuromutilin derivatives containing 1, 3, 4-oxadiazole were designed and synthesized as potential antibacterial agents against Methicillin-resistant staphylococcus aureus (MRSA). The ultrasound-assisted reaction was proposed as a green chemistry method to synthesize 1, 3, 4-oxadiazole derivatives (intermediates 85–110). Among these pleuromutilin derivatives, compound 133 was found to be the strongest antibacterial derivative against MRSA (MIC = 0.125 μg/mL). Furthermore, the result of the time-kill curves displayed that compound 133 could inhibit the growth of MRSA in vitro quickly (- 4.36 log10 CFU/mL reduction). Then, compound 133 (- 1.82 log10 CFU/mL) displayed superior in vivo antibacterial efficacy than tiamulin (- 0.82 log10 CFU/mL) in reducing MRSA load in mice thigh model. Besides, compound 133 exhibited low cytotoxicity to RAW 264.7 cells. Molecular docking studies revealed that compound 133 was successfully localized in the binding pocket of 50S ribosomal subunit (ΔGb = -10.50 kcal/mol). The results indicated that these pleuromutilin derivatives containing 1, 3, 4-oxadiazole might be further developed into novel antibiotics against MRSA.

Process for the Preparation of Triazole Antifungal Drug, Its Intermediates and Polymorphs Thereof


Paragraph 0335, (2014/12/09)

A process for the preparation of 4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one compound of formula-1, its intermediates and polymorphs thereof. (I)

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