L-Aspartic acid, N-(4-chlorobenzoyl)-, 4-ethyl ester

Base Information

• Chemical Name: L-Aspartic acid, N-(4-chlorobenzoyl)-, 4-ethyl ester
• CAS No.: 68430-42-2
• Molecular Formula: C13H14ClNO5
• Molecular Weight: 299.711
• Mol file: 68430-42-2.mol

Synonyms:

Chemical Property of L-Aspartic acid, N-(4-chlorobenzoyl)-, 4-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Aspartic acid, N-(4-chlorobenzoyl)-, 4-ethyl ester

There total 1 articles about L-Aspartic acid, N-(4-chlorobenzoyl)-, 4-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-benzoyl chloride (122-01-0) + aspartic acid β-ethyl ester hydrochloride (58485-25-9) → N-(4-chlorobenzoyl)aspartic acid β-ethyl ester (68430-42-2)

Guidance literature:

With sodium carbonate; Yield given. Multistep reaction; 1.) water, acetone, 5 deg C, 1 h; 2.) 20 deg C, 1 h;

DOI:10.1248/cpb.34.4516

Reference yield: 93.0%

N-(4-chlorobenzoyl)aspartic acid β-ethyl ester (68430-42-2) → 2-(4-chlorophenyl)-4-ethoxycarbonylmethyl-5-oxo-2-oxazoline (94609-35-5)

Guidance literature:

In acetic anhydride; toluene; at 50 ℃; for 2h;

DOI:10.1248/cpb.34.4516

Reference yield:

N-(4-chlorobenzoyl)aspartic acid β-ethyl ester (68430-42-2) → ethyl 3-(4-chlorobenzoylamino)-4-oxo-4-phenylbutyrate (99923-51-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / toluene; acetic anhydride / 2 h / 50 °C

2: 3.) acetic acid / 1.) pyridine, r.t., 1 h; 2.) 50-60 deg C, 2 h; 3.) 55 deg C, 2 h

With acetic acid; In acetic anhydride; toluene;

DOI:10.1248/cpb.34.4516

upstream raw materials:

4-chloro-benzoyl chloride

aspartic acid β-ethyl ester hydrochloride

Downstream raw materials:

2-(4-chlorophenyl)-4-ethoxycarbonylmethyl-5-oxo-2-oxazoline

ethyl 3-(4-chlorobenzoylamino)-4-oxo-4-(2-propyl)butyrate

ethyl 3-(4-chlorobenzoylamino)-4-oxo-4-phenylbutyrate

ethyl 3-(4-chlorobenzoylamino)-4-oxo-4-(3-pyridyl)butyrate