alpha-Kosin

Base Information

• Chemical Name: alpha-Kosin
• CAS No.: 568-50-3
• Molecular Formula: C25H32 O8
• Molecular Weight: 460.524
• DSSTox Substance ID: DTXSID70205348
• Nikkaji Number: J9.423D
• Wikidata: Q27108611
• Metabolomics Workbench ID: 68251
• Mol file: 568-50-3.mol

Synonyms:alpha-kosin

Chemical Property of alpha-Kosin

Chemical Property:

• Melting Point: 192–193°C
• Boiling Point: 638°Cat760mmHg
• Flash Point: 211.3°C
• PSA: 133.52000
• Density: 1.234g/cm³
• LogP: 4.41120
• XLogP3: 5.6
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 8
• Exact Mass: 460.20971797
• Heavy Atom Count: 33
• Complexity: 623

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=C(C(=C1OC)C(=O)C(C)C)O)CC2=C(C(=C(C(=C2O)C)OC)C(=O)C(C)C)O)O

Technology Process of alpha-Kosin

There total 8 articles about alpha-Kosin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ Methylen-bis-pseudoaspidinol-iBiB (568-50-3)

Guidance literature:

With barium dihydroxide;

DOI:10.1002/ardp.18942320106

Reference yield:

2,6-Dihydroxy-4-methoxy-3-methyl-benzoesaeure-methylester (39828-28-9) → Methylen-bis-pseudoaspidinol-iBiB (568-50-3)

Guidance literature:

Multi-step reaction with 3 steps

1: BF₃, iPrCO₂H

2: (i) aq. KOH, (ii) Na₂CO₃

3: H₂O

With boron trifluoride; isobutyric Acid; In water;

Reference yield:

→ Methylen-bis-pseudoaspidinol-iBiB (568-50-3) + (2-hydroxy-5-isobutyryl-4,6-dimethoxy-3-methyl-phenyl)-(2,4,6-trihydroxy-3-isobutyryl-5-methyl-phenyl)-methane (1400-15-3)

Guidance literature:

With barium dihydroxide;

DOI:10.1002/ardp.18942320106

upstream raw materials:

formaldehyd

2,4-Dihydroxy-6-methoxy-5-methyl-isobutyrophenon

2,6-Dihydroxy-4-methoxy-3-methyl-benzoesaeure-methylester

2,6-Dihydroxy-3-isobutyryl-4-methoxy-5-methyl-benzoesaeuremethylester