Bicyclo[5.3.1]undec-7-en-3-one, 4-[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]butyl]-4,8,11,11-tetramethyl-2-( phenylmethoxy)-, (1S,2S,4R)-

Base Information

• Chemical Name: Bicyclo[5.3.1]undec-7-en-3-one, 4-[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]butyl]-4,8,11,11-tetramethyl-2-( phenylmethoxy)-, (1S,2S,4R)-
• CAS No.: 685077-43-4
• Molecular Formula: C42H56O3Si
• Molecular Weight: 636.99
• Mol file: 685077-43-4.mol

Synonyms:

Chemical Property of Bicyclo[5.3.1]undec-7-en-3-one, 4-[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]butyl]-4,8,11,11-tetramethyl-2-( phenylmethoxy)-, (1S,2S,4R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Bicyclo[5.3.1]undec-7-en-3-one, 4-[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]butyl]-4,8,11,11-tetramethyl-2-( phenylmethoxy)-, (1S,2S,4R)-

There total 2 articles about Bicyclo[5.3.1]undec-7-en-3-one, 4-[4-[[(1,1-dimethylethyl)diphenylsilyl]oxy]butyl]-4,8,11,11-tetramethyl-2-( phenylmethoxy)-, (1S,2S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(1R,2R,3S,4S)-2-{1-[4-(tert-butyldiphenylsilyloxy)butyl]vinyl}-1,5,5-trimethyl-6-methylene-3-(phenylmethoxy)bicyclo[2.2.2]octan-2-ol (685077-41-2) + methyl iodide (74-88-4) → (1S,2S,4R)-4-[4-(tert-butyldiphenylsilyloxy)butyl]-4,8,11,11-tetramethyl-2-(phenylmethoxy)bicyclo[5.3.1]undec-7-en-3-one (685077-43-4)

Guidance literature:

With potassium tert-butylate; In diethyl ether; at 18 ℃; for 5h;

DOI:10.1071/CH03161

Reference yield: 20.0%

(1R,2R,3S,4S)-2-{1-[4-(tert-butyldiphenylsilyloxy)butyl]vinyl}-1,5,5-trimethyl-6-methylene-3-(phenylmethoxy)bicyclo[2.2.2]octan-2-ol (685077-41-2) + methyl iodide (74-88-4) → (1S,2S,4R)-4-[4-(tert-butyldiphenylsilyloxy)butyl]-4,8,11,11-tetramethyl-2-(phenylmethoxy)bicyclo[5.3.1]undec-7-en-3-one (685077-43-4) + (1R,2R,3S,4S)-[5-(2-methoxy-1,5,5-trimethyl-6-methylene-3-(phenylmethoxy)bicyclo[2.2.2]oct-2-yl)-hex-5-enyloxy]-tert-butyldiphenylsilane

Guidance literature:

With potassium hydride; In 1,2-dimethoxyethane; at 50 ℃; for 2h;

DOI:10.1071/CH03161

Reference yield: 99.0%

(1S,2S,4R)-4-[4-(tert-butyldiphenylsilyloxy)butyl]-4,8,11,11-tetramethyl-2-(phenylmethoxy)bicyclo[5.3.1]undec-7-en-3-one (685077-43-4) → (1S,2S,4R)-4-(4-hydroxybutyl)-4,8,11,11-tetramethyl-2-(phenylmethoxy)bicyclo[5.3.1]undec-7-en-3-one (685077-52-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 18 ℃; for 3h;

DOI:10.1071/CH03161

upstream raw materials:

(1R,2R,3S,4S)-2-{1-[4-(tert-butyldiphenylsilyloxy)butyl]vinyl}-1,5,5-trimethyl-6-methylene-3-(phenylmethoxy)bicyclo[2.2.2]octan-2-ol

methyl iodide

Downstream raw materials:

(1S,2S,4R)-4-(4-hydroxybutyl)-4,8,11,11-tetramethyl-2-(phenylmethoxy)bicyclo[5.3.1]undec-7-en-3-one

(1R,3aR,7S,8S,8aR)-1-[4-(tert-butyldiphenylsilyloxy)butyl]-2,3,7,8-tetrahydro-1,4,9,9-tetramethyl-8-(phenylmethoxy)-1H-3a,7-methanoazulen-8a(6H)-ol

(4R,6S,7S)-4-{4,10,11,11-tetramethyl-5-oxo-6-(phenylmethoxy)bicyclo[5.3.1]undec-1⁽¹⁰⁾-en-4-yl}butyraldehyde

(1S,2S,4R)-4-(4-bromobutyl)-4,8,11,11-tetramethyl-2-(phenylmethoxy)bicyclo[5.3.1]undec-7-ene-3,9-dione