Technology Process of 3-Oxazolidinecarboxylic acid,
5-[[[(1S)-1-(methoxycarbonyl)-3-methylbutyl]amino]carbonyl]-2,2-dimeth
yl-4-(phenylmethyl)-, 1,1-dimethylethyl ester, (4R,5S)-
There total 8 articles about 3-Oxazolidinecarboxylic acid,
5-[[[(1S)-1-(methoxycarbonyl)-3-methylbutyl]amino]carbonyl]-2,2-dimeth
yl-4-(phenylmethyl)-, 1,1-dimethylethyl ester, (4R,5S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: activated Al2O3 / 24 h / -20 °C
2: H2 / Raney-Ni / methanol / 16 h / 20 °C
3: 185 mg / aq. NaHCO3 / ethyl acetate / 2 h / 20 °C
4: 87 percent / TsOH / toluene / 5 h / 50 °C
5: 89 percent / MeONa / methanol / 24 h / 20 °C
6: 95 percent / N-ethylmorpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / -5 - 20 °C
With
N-ethylmorpholine;; aluminum oxide; hydrogen; sodium methylate; sodium hydrogencarbonate; toluene-4-sulfonic acid; isobutyl chloroformate;
nickel;
In
tetrahydrofuran; methanol; ethyl acetate; toluene;
DOI:10.1021/jo0358269
- Guidance literature:
-
Multi-step reaction with 5 steps
1: H2 / Raney-Ni / methanol / 16 h / 20 °C
2: 185 mg / aq. NaHCO3 / ethyl acetate / 2 h / 20 °C
3: 87 percent / TsOH / toluene / 5 h / 50 °C
4: 89 percent / MeONa / methanol / 24 h / 20 °C
5: 95 percent / N-ethylmorpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / -5 - 20 °C
With
N-ethylmorpholine;; hydrogen; sodium methylate; sodium hydrogencarbonate; toluene-4-sulfonic acid; isobutyl chloroformate;
nickel;
In
tetrahydrofuran; methanol; ethyl acetate; toluene;
DOI:10.1021/jo0358269
