139397-07-2

Upstream product

• 81926-51-4 N-(tert-butyloxycarbonyl)-(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoic acid methyl ester 
• 77119-85-8 N-(tert-butoxycarbonyl)-D-phenylalaninal 
• 19901-50-9 methyl (2R)-2-(t-butoxycarbonylamino)-3-phenylpropionate 
• 13033-84-6 D-phenylalanine methyl ester hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 640279-64-7 O-[(3R)-tert-butoxycarbonylamino-(2S)-hydroxy-4-phenylbutanoyl]-(1'R,2'S,5'R)-8'-phenylmenthol 
• 640279-63-6 O-[(2S)-hydroxy-(3R)-3-nitro-4-phenylbutanoyl]-(1'R,2'S,5'R)-8'-phenylmenthol 
• 767337-71-3 (3aS,6R,7aR)-tetrahydro-3-[(2S,3R)-2-hydroxy-3-nitro-4-phenylbutanoyl]-8,8-dimethyl-3a,6-methano-1,3-benzoxazol-2(4H)-one 
• 6125-24-2 2-Phenylnitroethane 
• 685508-06-9 O-[(3R)-tert-butoxycarbonylamino-(2S)-hydroxy-2,3-isopropylidene-4-phenylbutanoyl]-(1'R,2'S,5'R)-8'-phenylmenthol 
• 204460-76-4 (4R,5S)-4-Benzyl-2,2-dimethyl-oxazolidine-3,5-dicarboxylic acid 3-tert-butyl ester 5-methyl ester 

Downstream Products

• 114886-76-9 (2(S)-hydroxy-3(R)-amino-4-phenylthiobutanoyl)-L-leucine trifluoroacetate 
• 145902-56-3 tert-Butyl (4R,5S)-4-benzyl-5-(((2S)-1-(tert-butoxy)-4-methyl-1-oxopentan-2-yl)-carbamoyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate 
• 223763-80-2 bestatin trifluroacetate salt 
• 65322-89-6 methyl (2S)-2-(((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)amino)-4-methylpentanoate 
• 65391-42-6 Bestatin hydrochloride 
• 685508-11-6 [(3R)-tert-butoxycarbonylamino-(2S)-hydroxy-2,3-isopropylidene-4-phenylbutanoyl]-L-leucine methyl ester 

Relevant academic research and scientific papers

A practical diastereoselective synthesis of (?)-bestatin

Diastereoselective addition of nitromethane to Boc-D-Phe-H in the presence of sodium hydride in diethyl ether/hexane containing 15-crown-5 and subsequent N,O-protection with 2,2-dimethoxypropane gave trans-oxazolidine in a diastereomeric ratio of >16:1. T

Asymmetric reaction of simple nitro compounds with chiral 1,3-oxazolidin-2-ones

The chiral oxazolidinone 1 (=[(3aS,6R,7aR)-tetrahydro-8,8-dimethyl-2-oxo4H- 3a,6-methano-1,3-benzoxazol-3-yl](oxo)acetaldehyde) was found to react stereoselectively with simple nitro compounds in the presence of Al 2O3 or Bu4/s

Asymmetric Nitroaldol Reaction. Synthesis of Taxotere Side Chain and (-)-Bestatin Using (1R)-8-Phenylmenthyl Glyoxylate

The nitroaldol reaction of (1R)-8-phenylmenthyl glyoxylate (3b) with 1-nitro-1-phenylmethane (4) or with 1-nitro-2-phenylethane (13) led stereoselectively to adducts syn-2b and syn-12b, which were then transformed into the Taxotere side chain and (-)-best

Synthesis of (-)-bestatin and the Taxotere side-chain via nitroaldol reaction of (1R)-8-phenylmenthyl glyoxylate

The nitroaldol reaction of (1R)-8-phenylmenthyl glyoxylate 6 with 1-nitro-2-phenylethane or with phenylnitromethane led stereoselectively to adducts 4 and 12, which where then transformed into (-)-bestatin hydrochloride and the Taxotere side-chain in over

Development of selective tight-binding inhibitors of leukotriene A4 hydrolase

Leukotriene A4 hydrolase is a zinc-containing enzyme which exhibits both epoxide hydrolase and aminopeptidase activities. Since the enzyme product leukotriene B4 is an inflammatory mediator, it is of interest to develop selective inh

Tuftsin derivatives

Linear or cyclic tetra peptide derivatives of tuftsin which activate immunocompetent cells, i.e., macrophages and polymorphonuclear leukocyte, provide a host-mediated inhibition of the growth of tumors, provide protective effects for infectious diseases s