Piperazine, 1-[(2E)-3-[4-chloro-2-[(4-hydroxy-1-methyl-4-piperidinyl)ethynyl]phenyl]- 1-oxo-2-propenyl]-4-[(4-fluorophenyl)methyl]-2-methyl-, (2R)-

Base Information

Chemical Name:Piperazine, 1-[(2E)-3-[4-chloro-2-[(4-hydroxy-1-methyl-4-piperidinyl)ethynyl]phenyl]- 1-oxo-2-propenyl]-4-[(4-fluorophenyl)methyl]-2-methyl-, (2R)-
CAS No.:685534-51-4
Molecular Formula:C29H33ClFN3O2
Molecular Weight:510.051
Hs Code.:

Piperazine,
1-[(2E)-3-[4-chloro-2-[(4-hydroxy-1-methyl-4-piperidinyl)ethynyl]phenyl]-
1-oxo-2-propenyl]-4-[(4-fluorophenyl)methyl]-2-methyl-, (2R)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Piperazine, 1-[(2E)-3-[4-chloro-2-[(4-hydroxy-1-methyl-4-piperidinyl)ethynyl]phenyl]- 1-oxo-2-propenyl]-4-[(4-fluorophenyl)methyl]-2-methyl-, (2R)-

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Technology Process of Piperazine, 1-[(2E)-3-[4-chloro-2-[(4-hydroxy-1-methyl-4-piperidinyl)ethynyl]phenyl]- 1-oxo-2-propenyl]-4-[(4-fluorophenyl)methyl]-2-methyl-, (2R)-

There total 1 articles about Piperazine, 1-[(2E)-3-[4-chloro-2-[(4-hydroxy-1-methyl-4-piperidinyl)ethynyl]phenyl]- 1-oxo-2-propenyl]-4-[(4-fluorophenyl)methyl]-2-methyl-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 20734-46-7
1-Methyl-4-ethynylpiperidin-4-ol

: 685534-54-7
(E)-3-(2-bromo-4-chlorophenyl)-1-[(R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl]propenone

: 685534-51-4
(E)-3-[4-chloro-2-(4-hydroxy-1-methylpiperidin-4-ylethynyl)-phenyl]-1-[(R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl]-propenone

Guidance literature:: With copper(l) iodide; caesium carbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In diethylene glycol dimethyl ether; at 130 ℃; for 0.416667h;