(E)-3-(2-bromo-4-chlorophenyl)-1-[(R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl]propenone

Base Information

Chemical Name:(E)-3-(2-bromo-4-chlorophenyl)-1-[(R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl]propenone
CAS No.:685534-54-7
Molecular Formula:C₂₁H₂₁BrClFN₂O
Molecular Weight:451.766
Hs Code.:

Synonyms:(E)-3-(2-bromo-4-chlorophenyl)-1-[(R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl]propenone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-(2-bromo-4-chlorophenyl)-1-[(R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl]propenone

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Technology Process of (E)-3-(2-bromo-4-chlorophenyl)-1-[(R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl]propenone

There total 1 articles about (E)-3-(2-bromo-4-chlorophenyl)-1-[(R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl]propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 422270-29-9
(R)-1-(4-fluorobenzyl)-3-methylpiperazine

: 685534-53-6
(E)-3-(2-bromo-4-chlorophenyl)-acrylic acid

: 685534-54-7
(E)-3-(2-bromo-4-chlorophenyl)-1-[(R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl]propenone

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;

Reference yield: 78.0%

: 685534-54-7
(E)-3-(2-bromo-4-chlorophenyl)-1-[(R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl]propenone

: 2978-58-7
1,1-dimethylprop-3-ynylamine

: 685534-58-1
(E)-3-[2-(3-amino-3-methylbut-1-ynyl)-4-chlorophenyl]-1-[(R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl]-propenone

Guidance literature:: With copper(l) iodide; caesium carbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In diethylene glycol dimethyl ether; at 130 ℃; for 0.416667h;

Reference yield: 78.0%

: 20734-46-7
1-Methyl-4-ethynylpiperidin-4-ol

: 685534-54-7
(E)-3-(2-bromo-4-chlorophenyl)-1-[(R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl]propenone

: 685534-51-4
(E)-3-[4-chloro-2-(4-hydroxy-1-methylpiperidin-4-ylethynyl)-phenyl]-1-[(R)-4-(4-fluorobenzyl)-2-methylpiperazin-1-yl]-propenone

Guidance literature:: With copper(l) iodide; caesium carbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In diethylene glycol dimethyl ether; at 130 ℃; for 0.416667h;