1H-Pyrrole-2-propanoic acid, 4-(2,5-difluorophenyl)-1-[(dimethylamino)carbonyl]-2,5-dihydro-2-phenyl -, methyl ester, (2S)-

Base Information

• Chemical Name: 1H-Pyrrole-2-propanoic acid, 4-(2,5-difluorophenyl)-1-[(dimethylamino)carbonyl]-2,5-dihydro-2-phenyl -, methyl ester, (2S)-
• CAS No.: 686321-43-7
• Molecular Formula: C23H24F2N2O3
• Molecular Weight: 414.452
• Mol file: 686321-43-7.mol

Synonyms:

Chemical Property of 1H-Pyrrole-2-propanoic acid, 4-(2,5-difluorophenyl)-1-[(dimethylamino)carbonyl]-2,5-dihydro-2-phenyl -, methyl ester, (2S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1H-Pyrrole-2-propanoic acid, 4-(2,5-difluorophenyl)-1-[(dimethylamino)carbonyl]-2,5-dihydro-2-phenyl -, methyl ester, (2S)-

There total 16 articles about 1H-Pyrrole-2-propanoic acid, 4-(2,5-difluorophenyl)-1-[(dimethylamino)carbonyl]-2,5-dihydro-2-phenyl -, methyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H22F2N2O3 → C23H24F2N2O3 (686321-43-7)

Guidance literature:

With sodium tetrahydroborate; nickel dichloride; In methanol; at 0 ℃;

DOI:10.1016/j.bmcl.2007.03.006

Reference yield:

C20H20ClNO2 → C23H24F2N2O3 (686321-43-7)

Guidance literature:

Multi-step reaction with 15 steps

1.1: aq. HCl

2.1: Na₂CO₃ / H₂O

3.1: LAH / tetrahydrofuran / 0 - 20 °C

4.1: TEA / CH₂Cl₂

5.1: O₃ / CH₂Cl₂ / -78 °C

5.2: DMS / CH₂Cl₂

6.1: NaHMDS / tetrahydrofuran / -78 °C

6.2: tetrahydrofuran

7.1: Na₂CO₃; LiCl / Pd(Ph₃P)4 / 1,2-dimethoxy-ethane

8.1: aq. NaOH / ethanol / 60 °C

9.1: imidazole / CH₂Cl₂; dimethylformamide

10.1: TEA / tetrahydrofuran

11.1: HF-TEA / acetonitrile

12.1: 100 percent / Dess-Martin periodinane / CH₂Cl₂

13.1: 67 percent / NaH / tetrahydrofuran

14.1: NiCl₂; NaBH₄ / methanol / 0 °C

With 1H-imidazole; hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; TEA; sodium hexamethyldisilazane; sodium hydride; sodium carbonate; Dess-Martin periodane; ozone; lithium chloride; nickel dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 7.1: Suzuki reaction / 14.1: Horner-Wadsworth-Emmons reaction;

DOI:10.1016/j.bmcl.2007.03.006

Reference yield:

C13H16ClNO2*HCl → C23H24F2N2O3 (686321-43-7)

Guidance literature:

Multi-step reaction with 14 steps

1.1: Na₂CO₃ / H₂O

2.1: LAH / tetrahydrofuran / 0 - 20 °C

3.1: TEA / CH₂Cl₂

4.1: O₃ / CH₂Cl₂ / -78 °C

4.2: DMS / CH₂Cl₂

5.1: NaHMDS / tetrahydrofuran / -78 °C

5.2: tetrahydrofuran

6.1: Na₂CO₃; LiCl / Pd(Ph₃P)4 / 1,2-dimethoxy-ethane

7.1: aq. NaOH / ethanol / 60 °C

8.1: imidazole / CH₂Cl₂; dimethylformamide

9.1: TEA / tetrahydrofuran

10.1: HF-TEA / acetonitrile

11.1: 100 percent / Dess-Martin periodinane / CH₂Cl₂

12.1: 67 percent / NaH / tetrahydrofuran

13.1: NiCl₂; NaBH₄ / methanol / 0 °C

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; lithium aluminium tetrahydride; TEA; sodium hexamethyldisilazane; sodium hydride; sodium carbonate; Dess-Martin periodane; ozone; lithium chloride; nickel dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 6.1: Suzuki reaction / 13.1: Horner-Wadsworth-Emmons reaction;

DOI:10.1016/j.bmcl.2007.03.006

upstream raw materials:

6-(2,5-difluorophenyl)-7a-phenyl-5,7a-dihydro-1H-pyrrolo[1,2-c][1,3]oxazole-3-one

(2S)-4-(2,5-difluorophenyl)-2-phenyl-2-[(1,1,2,2-tetramethylpropoxy)methyl]-2,5-dihydro-1H-pyrrole

(2S)-4-(2,5-difluorophenyl)-2-(hydroxymethyl)-N,N-dimethyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

C₂₀H₁₈F₂N₂O₂

Downstream raw materials:

C₂₂H₂₄F₂N₂O₂

C₂₃H₂₂F₄N₂O₂