(2S)-4-(2,5-difluorophenyl)-2-(hydroxymethyl)-N,N-dimethyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

Base Information

Chemical Name:(2S)-4-(2,5-difluorophenyl)-2-(hydroxymethyl)-N,N-dimethyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide
CAS No.:956614-39-4
Molecular Formula:C₂₀H₂₀F₂N₂O₂
Molecular Weight:358.388
Hs Code.:

Synonyms:(2S)-4-(2,5-difluorophenyl)-2-(hydroxymethyl)-N,N-dimethyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

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Chemical Property of (2S)-4-(2,5-difluorophenyl)-2-(hydroxymethyl)-N,N-dimethyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

Chemical Property:

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Technology Process of (2S)-4-(2,5-difluorophenyl)-2-(hydroxymethyl)-N,N-dimethyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

There total 13 articles about (2S)-4-(2,5-difluorophenyl)-2-(hydroxymethyl)-N,N-dimethyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₃₄F₂N₂O₂Si

: 956614-39-4
(2S)-4-(2,5-difluorophenyl)-2-(hydroxymethyl)-N,N-dimethyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

Guidance literature:: With HF-TEA; In acetonitrile;
DOI:10.1016/j.bmcl.2007.03.006

Reference yield:

: C₂₀H₂₀ClNO₂

: 956614-39-4
(2S)-4-(2,5-difluorophenyl)-2-(hydroxymethyl)-N,N-dimethyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

Guidance literature:: Multi-step reaction with 12 steps

1.1: aq. HCl

2.1: Na₂CO₃ / H₂O

3.1: LAH / tetrahydrofuran / 0 - 20 °C

4.1: TEA / CH₂Cl₂

5.1: O₃ / CH₂Cl₂ / -78 °C

5.2: DMS / CH₂Cl₂

6.1: NaHMDS / tetrahydrofuran / -78 °C

6.2: tetrahydrofuran

7.1: Na₂CO₃; LiCl / Pd(Ph₃P)4 / 1,2-dimethoxy-ethane

8.1: aq. NaOH / ethanol / 60 °C

9.1: imidazole / CH₂Cl₂; dimethylformamide

10.1: TEA / tetrahydrofuran

11.1: HF-TEA / acetonitrile

With 1H-imidazole; hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; TEA; sodium hexamethyldisilazane; sodium carbonate; ozone; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 7.1: Suzuki reaction;
DOI:10.1016/j.bmcl.2007.03.006

Reference yield:

: C₁₃H₁₆ClNO₂*HCl

: 956614-39-4
(2S)-4-(2,5-difluorophenyl)-2-(hydroxymethyl)-N,N-dimethyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: Na₂CO₃ / H₂O

2.1: LAH / tetrahydrofuran / 0 - 20 °C

3.1: TEA / CH₂Cl₂

4.1: O₃ / CH₂Cl₂ / -78 °C

4.2: DMS / CH₂Cl₂

5.1: NaHMDS / tetrahydrofuran / -78 °C

5.2: tetrahydrofuran

6.1: Na₂CO₃; LiCl / Pd(Ph₃P)4 / 1,2-dimethoxy-ethane

7.1: aq. NaOH / ethanol / 60 °C

8.1: imidazole / CH₂Cl₂; dimethylformamide

9.1: TEA / tetrahydrofuran

10.1: HF-TEA / acetonitrile

With 1H-imidazole; sodium hydroxide; lithium aluminium tetrahydride; TEA; sodium hexamethyldisilazane; sodium carbonate; ozone; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 6.1: Suzuki reaction;
DOI:10.1016/j.bmcl.2007.03.006