1-N-BOC-6-METHOXY-3-METHYL-1H-INDAZOLE

Base Information

• Chemical Name: 1-N-BOC-6-METHOXY-3-METHYL-1H-INDAZOLE
• CAS No.: 691900-70-6
• Molecular Formula: C14H18N2O3
• Molecular Weight: 262.30400
• Mol file: 691900-70-6.mol

Synonyms:6-methoxy-3-methyl-1-H tert-butyl-6-methoxy-3-methyl-indazole 1-indazole-carboxylate;6-METHOXY-3-METHYL-1H-INDAZOLE-1-CARBOXYLIC ACID,1,1-DIMETHYLETHYL ESTER;tert-butyl-6-methoxy-3-methyl-1-indazole-carboxylate;6-METHOXY-3-METHYL-INDAZOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;TERT-BUTYL 6-METHOXY-3-METHYL-1H-INDAZOLE-1-CARBOXYLATE;1-N-BOC-6-METHOXY-3-METHYL-1H-INDAZOLE;1H-INDAZOLE-1-CARBOXYLIC ACID,6-METHOXY-3-METHYL-,1,1-DIMETHYLETHYL ESTER;

Chemical Property of 1-N-BOC-6-METHOXY-3-METHYL-1H-INDAZOLE

Chemical Property:

• PSA: 53.35000
• LogP: 3.13650

Purity/Quality:

≥95% ^*data from raw suppliers

tert-Butyl 6-methoxy-3-methyl-1H-indazole-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-N-BOC-6-METHOXY-3-METHYL-1H-INDAZOLE

There total 2 articles about 1-N-BOC-6-METHOXY-3-METHYL-1H-INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

di-tert-butyl dicarbonate (24424-99-5) + 6-methoxy-3-methyl-1H-indazole (7746-29-4) → tert-butyl-6-methoxy-3-methyl-1-indazole-carboxylate (691900-70-6)

Guidance literature:

With dmap; triethylamine; In acetonitrile; at 0 - 20 ℃;

Reference yield:

1-(2-fluoro-4-methoxyphenyl)-1-ethanone (74457-86-6) → tert-butyl-6-methoxy-3-methyl-1-indazole-carboxylate (691900-70-6)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine / ethylene glycol / 52 h / 20 - 150 °C

2: triethylamine / dmap / acetonitrile / 2 h / -5 - 20 °C

With triethylamine; hydrazine; dmap; In ethylene glycol; acetonitrile;

Reference yield:

tert-butyl-6-methoxy-3-methyl-1-indazole-carboxylate (691900-70-6) → 6-methoxy-1H-indazole-3-carbaldehyde (518987-37-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 5 h / Heating / reflux; sun lamp

2: sodium acetate / acetic acid / Heating / reflux

With N-Bromosuccinimide; sodium acetate; dibenzoyl peroxide; In tetrachloromethane; acetic acid;

upstream raw materials:

di-tert-butyl dicarbonate

6-methoxy-3-methyl-1H-indazole

1-(2-fluoro-4-methoxyphenyl)-1-ethanone

Downstream raw materials:

6-methoxy-1H-indazole-3-carbaldehyde

C₁₆H₁₄N₂O₃

C₂₇H₃₈N₂O₅Si

C₂₇H₃₆N₂O₅Si

Refernces

• 1、 -. "OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION". Page/Page column 14; 21. . Retrieved 2008/06/13.