2-Fluoro-4-methoxyacetophenone

Base Information

• Chemical Name: 2-Fluoro-4-methoxyacetophenone
• CAS No.: 74457-86-6
• Molecular Formula: C9H9FO2
• Molecular Weight: 168.168
• Hs Code.: 29147000
• Mol file: 74457-86-6.mol

Synonyms:1-(2-Fluoro-4-methoxyphenyl)ethanone;1-Acetyl-2-fluoro-4-methoxybenzene;2'-Fluoro-4'-methoxyacetophenone;

Chemical Property of 2-Fluoro-4-methoxyacetophenone

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Melting Point: 52-54 °C(lit.)
• Boiling Point: 243 °C at 760 mmHg
• Flash Point: 97.9 °C
• PSA: 26.30000
• Density: 1.127 g/cm³
• LogP: 2.03690
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility.: Insoluble

Purity/Quality:

99% ^*data from raw suppliers

2-Fluoro-4-methoxyacetophenone 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2′-Fluoro-4′-methoxyacetophenone may be used in chemical synthesis.

Technology Process of 2-Fluoro-4-methoxyacetophenone

There total 6 articles about 2-Fluoro-4-methoxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

→ 1-(2-fluoro-4-methoxyphenyl)-1-ethanone (74457-86-6)

Guidance literature:

Reference yield: 78.0%

1-(4-methoxyphenyl)ethanone (100-06-1) → 1-(2-fluoro-4-methoxyphenyl)-1-ethanone (74457-86-6)

Guidance literature:

With palladium diacetate; silver nitrate; N-fluorobis(benzenesulfon)imide; methyl carbamate; In dichloromethane; at 95 ℃; for 24h; Sealed tube;

DOI:10.1039/d1cc01047f

Reference yield: 70.0%

1-fluoro-3-methoxybenzene (456-49-5) + acetic anhydride (108-24-7) → 1-(4-fluoro-2-methoxy-phenyl)-ethanone (51788-80-8) + 1-(2-fluoro-4-methoxyphenyl)-1-ethanone (74457-86-6)

Guidance literature:

With lithium perchlorate; at 100 ℃; for 1h;

DOI:10.1016/S0040-4039(02)01368-0

upstream raw materials:

1-fluoro-3-methoxybenzene

acetic anhydride

1-(4-methoxyphenyl)ethanone

C₁₀H₁₂FNO₂

Downstream raw materials:

2-fluoro-4-methoxy-1-(1-phenyl-vinyl)-benzene

2-fluoro-4-methoxy-benzoic acid

1-(2-fluoro-4-methoxyphenyl)ethan-1-ol

6-methoxy-3-methyl-1H-indazole