5-bromo-N-[(4-chlorophenyl)methyl]pyridin-2-amine

Base Information

Chemical Name:5-bromo-N-[(4-chlorophenyl)methyl]pyridin-2-amine
CAS No.:694508-76-4
Molecular Formula:C12H10BrClN2
Molecular Weight:297.582
Hs Code.:
Mol file:694508-76-4.mol

Synonyms:2-PYRIDINAMINE,5-BROMO-N-[(4-CHLOROPHENYL)METHYL]-;2-PYRIDINAMINE, 5-BROMO-N-[(4-CHLOROPHENYL)METHYL]-;

Suppliers and Price of 5-bromo-N-[(4-chlorophenyl)methyl]pyridin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
2-Pyridinamine,5-bromo-N-[(4-chlorophenyl)methyl]- 95
10g
$ 2475.00

Labseeker
2-Pyridinamine,5-bromo-N-[(4-chlorophenyl)methyl]- 95
5g
$ 1833.00

American Custom Chemicals Corporation
2-PYRIDINAMINE, 5-BROMO-N-[(4-CHLOROPHENYL)METHYL]- 95.00%
5MG
$ 500.83

Total 4 raw suppliers

Chemical Property of 5-bromo-N-[(4-chlorophenyl)methyl]pyridin-2-amine

Chemical Property:

PSA：24.92000
LogP:4.18260

Purity/Quality:

99% ^*data from raw suppliers

2-Pyridinamine,5-bromo-N-[(4-chlorophenyl)methyl]- 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-bromo-N-[(4-chlorophenyl)methyl]pyridin-2-amine

There total 1 articles about 5-bromo-N-[(4-chlorophenyl)methyl]pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1072-97-5
5-bromo-2-pyridylamine

: 104-88-1
4-chlorobenzaldehyde

: 694508-76-4
(5-bromo-pyridin-2-yl)-(4-chloro-benzyl)-amine

Guidance literature:: 5-bromo-2-pyridylamine; 4-chlorobenzaldehyde; With triethylsilane; trifluoroacetic acid; In acetonitrile; Reflux;

With potassium carbonate;

Reference yield: 92.2%

: 694508-76-4
(5-bromo-pyridin-2-yl)-(4-chloro-benzyl)-amine

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 923562-60-1
6-(4-chloro-benzylamino)-pyridine-3-carbaldehyde

Guidance literature:: (5-bromo-pyridin-2-yl)-(4-chloro-benzyl)-amine; With n-butyllithium; In tetrahydrofuran; hexane; cyclohexane; at -78 ℃; for 2.83333h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; cyclohexane; at -78 - 20 ℃; for 3h;

With hydrogenchloride; water; In tetrahydrofuran; hexane; at 20 ℃;

Reference yield:

: 694508-76-4
(5-bromo-pyridin-2-yl)-(4-chloro-benzyl)-amine

: 923562-61-2
(4-chloro-benzyl)-(5-formyl-pyridin-2-yl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; cyclohexane / 1.5 h / -78 °C

1.2: 1.33 h / -78 °C

1.3: 3 h / -78 - 20 °C

2.1: dmap; triethylamine / dichloromethane / 48 h / 20 °C

With dmap; n-butyllithium; triethylamine; In tetrahydrofuran; dichloromethane; cyclohexane;