Benzamide, N-[(4S,5S)-2,2-dimethyl-4-[4-(methylthio)phenyl]-1,3-dioxan-5-yl]-2-[(5,6 ,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-yl)methyl]-

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Chemical Name:Benzamide, N-[(4S,5S)-2,2-dimethyl-4-[4-(methylthio)phenyl]-1,3-dioxan-5-yl]-2-[(5,6 ,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-yl)methyl]-
CAS No.:696659-66-2
Molecular Formula:C31H34N2O5S
Molecular Weight:546.687
Hs Code.:

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Chemical Property of Benzamide, N-[(4S,5S)-2,2-dimethyl-4-[4-(methylthio)phenyl]-1,3-dioxan-5-yl]-2-[(5,6 ,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-yl)methyl]-

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Technology Process of Benzamide, N-[(4S,5S)-2,2-dimethyl-4-[4-(methylthio)phenyl]-1,3-dioxan-5-yl]-2-[(5,6 ,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-yl)methyl]-

There total 4 articles about Benzamide, N-[(4S,5S)-2,2-dimethyl-4-[4-(methylthio)phenyl]-1,3-dioxan-5-yl]-2-[(5,6 ,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinolin-5-yl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 6882-28-6
norhydrastinine

: 696659-61-7
(1S,2S)-2-o-toluamide-1-[4-(methylthio)phenyl]-1,3-O-isopropylidene-1,3-propanediol

: 696659-66-2
N-[2,2-dimethyl-4-(4-methylsulfanyl-phenyl)-[1,3]dioxan-5-yl]-2-(5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-benzamide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -72 ℃; for 4h;
DOI:10.1016/j.tetasy.2004.02.017

Reference yield:

: 16854-32-3
(1S,2S)-(+)-thiomicamine

: 696659-66-2
N-[2,2-dimethyl-4-(4-methylsulfanyl-phenyl)-[1,3]dioxan-5-yl]-2-(5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / KOH / CH₂Cl₂; H₂O / 2.5 h / 0 - 20 °C

2: 49 percent / H₂SO₄ / acetone / 2 h

3: 57 percent / nBuLi / tetrahydrofuran; hexane / 4 h / -72 °C

With potassium hydroxide; n-butyllithium; sulfuric acid; In tetrahydrofuran; hexane; dichloromethane; water; acetone;
DOI:10.1016/j.tetasy.2004.02.017

Reference yield:

: 933-88-0
ortho-toluoyl chloride

: 696659-66-2
N-[2,2-dimethyl-4-(4-methylsulfanyl-phenyl)-[1,3]dioxan-5-yl]-2-(5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinolin-5-ylmethyl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / KOH / CH₂Cl₂; H₂O / 2.5 h / 0 - 20 °C

2: 49 percent / H₂SO₄ / acetone / 2 h

3: 57 percent / nBuLi / tetrahydrofuran; hexane / 4 h / -72 °C

With potassium hydroxide; n-butyllithium; sulfuric acid; In tetrahydrofuran; hexane; dichloromethane; water; acetone;
DOI:10.1016/j.tetasy.2004.02.017