Pyrido[3,4-d]pyriMidin-4(1H)-one, 5,6,7,8-tetrahydro-7-(phenylMethyl)-, Monohydrochloride

Base Information

• Chemical Name: Pyrido[3,4-d]pyriMidin-4(1H)-one, 5,6,7,8-tetrahydro-7-(phenylMethyl)-, Monohydrochloride
• CAS No.: 69981-00-6
• Molecular Formula: C14H15N3O.ClH
• Molecular Weight: 277.754
• Hs Code.: 2933990090
• Mol file: 69981-00-6.mol

Synonyms:7-benzyl-1,5,6,8-tetrahydropyrido[3,4-d]pyrimidin-4-one,hydrochloride;

Chemical Property of Pyrido[3,4-d]pyriMidin-4(1H)-one, 5,6,7,8-tetrahydro-7-(phenylMethyl)-, Monohydrochloride

Chemical Property:

• PSA: 48.99000
• LogP: 2.06810
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

7-Benzyl-5,6,7,8-tetrahydropyrido-[3,4-d]pyrimidin-4(1H)-one hydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrido[3,4-d]pyriMidin-4(1H)-one, 5,6,7,8-tetrahydro-7-(phenylMethyl)-, Monohydrochloride

There total 2 articles about Pyrido[3,4-d]pyriMidin-4(1H)-one, 5,6,7,8-tetrahydro-7-(phenylMethyl)-, Monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

formamidine acetic acid (3473-63-0) + ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride (52763-21-0) → 7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one (69981-00-6)

Guidance literature:

With sodium ethanolate; In ethanol; for 2.5h; Inert atmosphere; Reflux; Large scale;

DOI:10.1021/op0498114

Reference yield:

7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one (62458-96-2) → 7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one (69981-00-6)

Guidance literature:

With hydrogenchloride; In water; at 20 ℃;

Reference yield: 80.0%

7-benzyl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one (69981-00-6) → 7-benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine trihydrochloride (1255099-37-6)

Guidance literature:

With trichlorophosphate; In dichloromethane; at 0 ℃;

upstream raw materials:

7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one

formamidine acetic acid

ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

Downstream raw materials:

7-benzyl-4-chloro-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine trihydrochloride

7-Benzyl-4-chloro-5,6,7,8-tetrahydro-1,3,7-triazanaphthalene

7-benzyl-4-morpholin-4-yl-5,6,7,8-tetrahydro-pyrido[3,4-d]pyrimidine

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