3-HydroxyMethylpyrrole

Base Information

• Chemical Name: 3-HydroxyMethylpyrrole
• CAS No.: 71803-59-3
• Molecular Formula: C₅H₇NO
• Molecular Weight: 97.1167
• Mol file: 71803-59-3.mol

Synonyms:

Chemical Property of 3-HydroxyMethylpyrrole

Chemical Property:

• PSA: 36.02000
• LogP: 0.50700

Purity/Quality:

98% ^*data from raw suppliers

3-Hydroxymethylpyrrole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3-HydroxyMethylpyrrole can be used in a new synthesis of porphobilinogen and other trisubstituted pyrroles for photodynamic therap

Technology Process of 3-HydroxyMethylpyrrole

There total 2 articles about 3-HydroxyMethylpyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

pyrrole-3-carboxylic acid ethyl ester (37964-17-3) → 3-hydroxymethyl-1H-pyrrole (71803-59-3)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at 0 ℃; for 0.5h; Inert atmosphere;

DOI:10.1248/cpb.c16-00122

Reference yield:

1H-pyrrole-3-carboxylic acid (931-03-3) → 3-hydroxymethyl-1H-pyrrole (71803-59-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 1 h / 0 - 130 °C / Inert atmosphere; Microwave irradiation

2: diisobutylaluminium hydride / dichloromethane; toluene / 0.5 h / -78 °C / Inert atmosphere

With thionyl chloride; diisobutylaluminium hydride; In dichloromethane; toluene;

DOI:10.1016/j.ejmech.2015.06.028

upstream raw materials:

1H-pyrrole-3-carboxylic acid

pyrrole-3-carboxylic acid ethyl ester

Refernces

• 1、 Rupiani, Sebastiano,Buonfiglio, Rosa,Manerba, Marcella,Di Ianni, Lorenza,Vettraino, Marina,Giacomini, Elisa,Masetti, Matteo,Falchi, Federico,Di Stefano, Giuseppina,Roberti, Marinella,Recanatini, Maurizio. "Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors". . p. 63 - 70. Retrieved 2015/06/30.