2'-Fluoro-2',3'-dideoxyadenosine

Base Information

Chemical Name:2'-Fluoro-2',3'-dideoxyadenosine
CAS No.:110143-05-0
Molecular Formula:C₁₀H₁₂FN₅O₂
Molecular Weight:253.236
Hs Code.:2934999090
DSSTox Substance ID:DTXSID70149152
Nikkaji Number:J274.988B
Wikidata:Q83014841
ChEMBL ID:CHEMBL2114462
Mol file:110143-05-0.mol

Synonyms:2'-beta-F-ddAdo;2'-beta-fluoro-2',3'-dideoxyadenosine;2'-F-ara-ddA;2'-fluoro-2',3'-dideoxyadenosine;2'-fluoro-ara-2',3'-dideoxyadenosine;2'-fluoro-ribo-2',3'-dideoxyadenosine;9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)adenine;9-(2,3-dideoxy-2-fluoro-beta-threo-pentofuranosyl)adenine;F-ara-ddA;F-ribo-ddA;lodenosine;NSC 613792

Suppliers and Price of 2'-Fluoro-2',3'-dideoxyadenosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
2',3'-DIDEOXY-2'-FLUORO-ADENOSINE 95.00%
5MG
$ 498.58

Total 6 raw suppliers

Chemical Property of 2'-Fluoro-2',3'-dideoxyadenosine

Chemical Property:

Boiling Point:541.3°Cat760mmHg
Flash Point:281.2°C
PSA：99.08000
Density:1.85g/cm³
LogP:0.60760
XLogP3:-0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:253.09750280
Heavy Atom Count:18
Complexity:310

Purity/Quality:

97% ^*data from raw suppliers

2',3'-DIDEOXY-2'-FLUORO-ADENOSINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(OC(C1F)N2C=NC3=C(N=CN=C32)N)CO
Isomeric SMILES:C1[C@H](O[C@H]([C@@H]1F)N2C=NC3=C(N=CN=C32)N)CO

Technology Process of 2'-Fluoro-2',3'-dideoxyadenosine

There total 10 articles about 2'-Fluoro-2',3'-dideoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 125542-19-0
9-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-fluoro-tetrahydro-furan-2-yl}-9H-purin-6-ylamine

: 110143-05-0,166411-50-3
9-(2,3-dideoxy-2-fluoro-β-D-erythro-pentofuranosyl)adenine

Guidance literature:: With trichloroacetic acid; In dichloromethane; for 0.0833333h; Ambient temperature;
DOI:10.1021/jm00165a015

Reference yield: 92.0%

: 9-[5-(tert-butyl-dimethyl-silanyloxymethyl)-3-fluoro-tetrahydro-furan-2-yl]-9H-purin-6-ylamine

: 110143-05-0,166411-50-3
9-(2,3-dideoxy-2-fluoro-β-D-erythro-pentofuranosyl)adenine

Guidance literature:: With trifluoroacetic acid; In methanol; at 0 ℃; for 12h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b00391

Reference yield:

: 6998-75-0
3'-deoxydenosine

: 110143-05-0,166411-50-3
9-(2,3-dideoxy-2-fluoro-β-D-erythro-pentofuranosyl)adenine

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / pyridine / 48 h / Ambient temperature

2: (diethylamino)sulfur trifluoride (DAST) / CH₂Cl₂ / 14 h / Ambient temperature

3: p-toluenesulfonic acid / CHCl₃; methanol / 0.25 h / Ambient temperature

With pyridine; diethylamino-sulfur trifluoride; toluene-4-sulfonic acid; In methanol; dichloromethane; chloroform;
DOI:10.1021/jm00394a034