Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2',3'-dideoxy-2'-fluoro-

Base Information

Chemical Name:Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2',3'-dideoxy-2'-fluoro-
CAS No.:125542-19-0
Molecular Formula:C₃₁H₃₀FN₅O₄
Molecular Weight:555.609
Hs Code.:
DSSTox Substance ID:DTXSID601143176

Synonyms:DTXSID601143176;Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2',3'-dideoxy-2'-fluoro-;125542-19-0

Suppliers and Price of Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2',3'-dideoxy-2'-fluoro-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2',3'-dideoxy-2'-fluoro-

Chemical Property:

XLogP3:5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:9
Exact Mass:555.22818262
Heavy Atom Count:41
Complexity:796

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4CC(C(O4)N5C=NC6=C(N=CN=C65)N)F
Isomeric SMILES:COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OC[C@@H]4C[C@H]([C@@H](O4)N5C=NC6=C(N=CN=C65)N)F

Technology Process of Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2',3'-dideoxy-2'-fluoro-

There total 4 articles about Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2',3'-dideoxy-2'-fluoro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 111727-02-7
Trifluoro-methanesulfonic acid (2R,3S,5S)-2-(6-amino-purin-9-yl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester

: 125542-19-0
9-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-fluoro-tetrahydro-furan-2-yl}-9H-purin-6-ylamine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h; Ambient temperature;
DOI:10.1021/jm00165a015

Reference yield:

: 6998-75-0
3'-deoxydenosine

: 125542-19-0
9-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-fluoro-tetrahydro-furan-2-yl}-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 37 percent / DMAP, Et₃N, pyridine / 16 h / Ambient temperature

2: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) 2 h

3: 78 percent / 1M tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

With pyridine; dmap; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm00165a015

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 125542-19-0
9-{(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-fluoro-tetrahydro-furan-2-yl}-9H-purin-6-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 37 percent / DMAP, Et₃N, pyridine / 16 h / Ambient temperature

2: 1.) NaH / 1.) THF, 0 deg C, 1 h, 2.) 2 h

3: 78 percent / 1M tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

With pyridine; dmap; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; In tetrahydrofuran;
DOI:10.1021/jm00165a015