ethyl 3-amino-4-(4-methoxyphenyl)-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxylate

Base Information

• Chemical Name: ethyl 3-amino-4-(4-methoxyphenyl)-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxylate
• CAS No.: 723745-10-6
• Molecular Formula: C21H18N2O3S2
• Molecular Weight: 410.518
• Mol file: 723745-10-6.mol

Synonyms:3-Amino-4-(4-methoxy-phenyl)-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid ethyl ester;

Chemical Property of ethyl 3-amino-4-(4-methoxyphenyl)-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxylate

Chemical Property:

• Melting Point: 185 °C (CHCl3)
• PSA: 130.92000
• LogP: 6.04050

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-amino-4-(4-methoxyphenyl)-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxylate

There total 3 articles about ethyl 3-amino-4-(4-methoxyphenyl)-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

[3-cyano-4-(4-methoxy-phenyl)-6-thiophen-2-yl-pyridin-2-ylsulfanyl]-acetic acid ethyl ester (847976-23-2) → ethyl 3-amino-4-(4-methoxyphenyl)-6-(thiophen-2-yl)thieno[2,3-b]pyridine-2-carboxylate (723745-10-6)

Guidance literature:

With sodium ethanolate; In ethanol; for 0.0833333h; Heating;

DOI:10.1080/10426500490467147

Reference yield:

4-(4-methoxyphenyl)-6-(thiophen-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile (128342-41-6) → ethyl 3-amino-4-(4-methoxyphenyl)-6-(thiophen-2-yl)thieno[2,3-b]pyridine-2-carboxylate (723745-10-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / sodium acetate trihydrate / ethanol / 2 h / Heating

2: 90 percent / NaOEt / ethanol / 0.08 h / Heating

With sodium ethanolate; sodium acetate; In ethanol;

DOI:10.1080/10426500490467147

Reference yield:

(2E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one (6028-93-9) → ethyl 3-amino-4-(4-methoxyphenyl)-6-(thiophen-2-yl)thieno[2,3-b]pyridine-2-carboxylate (723745-10-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / piperidine / ethanol / 4 h / Heating

2: 97 percent / sodium acetate trihydrate / ethanol / 2 h / Heating

3: 90 percent / NaOEt / ethanol / 0.08 h / Heating

With piperidine; sodium ethanolate; sodium acetate; In ethanol;

DOI:10.1080/10426500490467147

upstream raw materials:

[3-cyano-4-(4-methoxy-phenyl)-6-thiophen-2-yl-pyridin-2-ylsulfanyl]-acetic acid ethyl ester

4-(4-methoxyphenyl)-6-(thiophen-2-yl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile

(2E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one

Downstream raw materials:

3-amino-4-(4-methoxy-phenyl)-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carbonyl azide

3-amino-N-(3-cyano-4,6-dimethyl-2-oxopyridin-1(2H)-yl)-4-(4-methoxyphenyl)-6-(thiophen-2-yl)thieno[2,3-b]pyridine-2-carboxamide