128342-41-6

Upstream product

• 88-15-3 2-Acetylthiophene 
• 68029-57-2 2-cyano-3-(4-methoxyphenyl)thioacrylamide 
• 39145-31-8 2-cyano-3-(4-methoxyphenyl)thioacrylamide 
• 137444-51-0 (2E)-3-(4-methoxyphenyl)-1-thiophen-2-yl-prop-2-en-1-one 
• 109-77-3 malononitrile 
• 7357-70-2 Cyanothioacetamide 
• 6028-93-9 (2E)-3-(4-methoxyphenyl)-1-(thiophen-2-yl) prop-2-en-1-one 
• 326-91-0 1,1,1-trifluoro-4-(2-thienyl)butane-2,4-dione 
• 123-11-5 4-methoxy-benzaldehyde 
• 39145-35-2 2-cyano-3-thiophen-2-yl-thioacrylamide 
• 2972-85-2 2-(1-(4-methoxyphenyl)ethylidene)malononitrile 

Downstream Products

• 539829-71-5 (3-cyano-4-(p-methoxyphenyl)-6-(2'-thienyl)-2-pyridinylthio)acetonitrile 
• 354556-40-4 3-amino-4-(p-methoxyphenyl)-6-(2'-thienyl)-thieno[2,3-b]pyridine-2-carbonitrile 
• 313380-19-7 (3-cyano-4-(p-methoxyphenyl)-6-(2'-thienyl)-2-pyridinylthio)acetamide 
• 330182-01-9 3-amino-4-(p-methoxyphenyl)-6-(2'-thienyl)-thieno[2,3-b]pyridine-2-carboxamide 
• 847976-63-0 3-amino-4-(4-methoxy-phenyl)-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carbonyl azide 
• 723745-10-6 ethyl 3-amino-4-(4-methoxyphenyl)-6-(thiophen-2-yl)thieno[2,3-b]pyridine-2-carboxylate 
• 847976-28-7 3-amino-4-(4-methoxy-phenyl)-6-thiophen-2-yl-thieno[2,3-b]pyridine-2-carboxylic acid hydrazide 
• 1145777-12-3 4-(4-methoxyphenyl)-6-(2-thienyl)-1H-pyrazolo[3,4-b]pyridin-3-amine 
• 329720-96-9 4-(4-methoxyphenyl)-2-(methylthio)-6-(2-thienyl)-nicotinonitrile 

Relevant academic research and scientific papers

ACETYL-COA CARBOXYLASE MODULATORS

Provided herein are compounds that exhibit activity as acetyl-CoA carboxylase modulators (e.g., inhibitors) and are useful, for example, in methods for the control of fungal pathogens in plants.

Studies on the synthesis of some new cyanopyridine-thione and thieno[2,3-b]pyridine derivatives

The work included in this article involves the synthesis of new cyanopyridinethiones as good synthons for new thieno[2,3-b]pyridines with anticipated biological activities. Thus, the reaction of -aryl - thiocarbamoylacrylonitrile (1a-c) with (2-thenoyl)-,-trifluoroacetone led to an unexpected formation of 4-aryl-3-cyano-6-(2-thienyl)pyridine-2(1H)-thiones (4a-c). In contrast, the reaction of 1a,b with ethyl acetoacetate produced 4-aryl-3-cyano-5-ethoxycarbonyl-6-methylpyridine-2(1H)-thiones (12a,b). The reaction of compound 4a with methyl iodide gave 2-methylthio derivative 6, which upon treatment with hydrazine hydrate furnished pyrazolopyridine 7. Treatment of 4a-c with chloroacetaimde, in the presence of sodium ethoxide, led to the formation of 3-amino-4-aryl-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxamides (8a-c). The reactions of 8a with some aromatic aldehydes and/or cycloalkanones were carried out and their products were identified. Compounds 12a,b were reacted with chloro-N-arylacetamides to give ethyl 4-aryl-2-(N-aryl) carbamoylmethylthio-3-cyano-6-methylpyridine-5-carboxylates (13a-j). Upon treatment of compounds 13a-j with sodium alkoxide in alcohol, they underwent an intramolecular Thorpe-Ziegler cyclization to furnish ethyl 3-amino-4-aryl-2-(N- aryl)carbamoyl-6-methylthieno[2,3-b]pyridine-5-carboxylates (14a-j). Compounds 14a-j, in turn, were reacted with triethyl orthoformate and/or carbon disulfide to give corresponding pyridothienopyrimidinone derivatives 15a-j and 18. Pyridothienotriazinone analogs 17a-j were synthesized via diazotisation of compounds 14a-j.

Synthesis and reactions of some new heterocyclic compounds containing the thienylthieno[2,3-b]pyridine moiety

(4-Aryl-3-cyano-6-(2-thienyl)pyridin-2-ylthio)acethydrazides (5a-c), 3-amino-4-aryl-6-(2-thienyl)thieno[2,3-b]pyridine-2-carbohydrazides (6a-c) and 3-amino-4-phenyl-6-(2-thienyl)thieno[2,3-b]pyridine-2-carboxylic acid (30) were prepared and employed as key intermediates in the synthesis of the title compounds.

One-pot synthesis of 4,6-diaryl-3-cyanopyridine-2(1H)-thiones and their transformation to substituted thieno[2,3-b;4,5-b]dipyridines and pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines

4,6-Diaryl-3-cyanopyridine-2(1H)-thiones were synthesized in one step by the reaction of elemental sulfur, malononitrile, and 2-aryl-1-aroylethylenes in the presence of excess triethylamine. The products were used in one-pot syntheses of substituted thien

Some reactions of 2-functionalized 3-amino-4-aryl-6-(2′-thienyl)-thieno[2,3-B]-pyridines: Synthesis of new pyridothienopyrimidines, pyridothienotriazines and related fused tetracyclic systems

4-Aryl-3-cyano-6-(2′-thienyl)-pyridine-2(1H)-thiones (2a-c) were prepared and reacted with chloroacetonitrile or chloroacetamide to furnish 3-amino-4-aryl-6-(2′-thienyl)-thieno[2,3-b]pyridine-2-carbonitriles (4a-c) and 2-carboxamide analogs 6a-c respectiv

Synthesis and antibacterial properties of new dithienyl containing pyran, pyrano[2,3-b] pyridine, pyrano[2,3-d]pyrimidine and pyridine derivatives

Some new pyran 3,8; pyrano[2,3-b]pyridine 4; pyrano[2,3-d] pyrimidine 5,6,7 and 9; pyridine 10-14 derivatives have been prepared. The structure of all the new compounds have been established on the basis of elemental analyses and spectroscopic data. All t

NOVEL SYNTHETIC ROUTE TO PYRIDINE-2(1H)-THIONES: UNEXPECTED PRODUCTS OF THE REACTION OF β-PHENETHYLIDENEMALONONITRILES WITH ARYLMETHYLENECYANOTHIOACETAMIDES

A novel synthesis of 3-cyanopyridine-2(1H)-thione derivatives utilizing arylmethylenecyanothioacetamides and β-phenethylidenemalononitriles as starting components is described.