ethyl 3-amino-2-[(4-methoxyanilino)carbonyl]-4-(4-methoxyphenyl)-6-methylthieno[2,3-b]pyridine-5-carboxylate

Base Information

Chemical Name:ethyl 3-amino-2-[(4-methoxyanilino)carbonyl]-4-(4-methoxyphenyl)-6-methylthieno[2,3-b]pyridine-5-carboxylate
CAS No.:723745-22-0
Molecular Formula:C26H25N3O5S
Molecular Weight:491.55900
Hs Code.:
Mol file:723745-22-0.mol

Synonyms:3-Amino-4-(4-methoxy-phenyl)-2-(4-methoxy-phenylcarbamoyl)-6-methyl-thieno[2,3-b]pyridine-5-carboxylic acid ethyl ester;

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Chemical Property of ethyl 3-amino-2-[(4-methoxyanilino)carbonyl]-4-(4-methoxyphenyl)-6-methylthieno[2,3-b]pyridine-5-carboxylate

Chemical Property:

Melting Point:172 - 173 °C (ethanol)
PSA：141.01000
LogP:5.95430

Purity/Quality:

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Technology Process of ethyl 3-amino-2-[(4-methoxyanilino)carbonyl]-4-(4-methoxyphenyl)-6-methylthieno[2,3-b]pyridine-5-carboxylate

There total 6 articles about ethyl 3-amino-2-[(4-methoxyanilino)carbonyl]-4-(4-methoxyphenyl)-6-methylthieno[2,3-b]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 924272-34-4
ethyl 5-cyano-6-({2-[(4-methoxyphenyl)amino]-2-oxoethyl}thio)-4-(4-methoxyphenyl)-2-methylnicotinate

: 723745-22-0
ethyl 3-amino-2-{[(4-methoxyphenyl)amino]carbonyl}-4-(4-methoxyphenyl)-6-methylthieno[2,3-b]pyridine-5-carboxylate

Guidance literature:: With sodium ethanolate; In ethanol; for 0.0833333h; Heating;
DOI:10.1080/10426500601096369

Reference yield: 63.0%

: 97651-29-1
ethyl 3-cyano-1,2-dihydro-4-p-methoxyphenyl-6-methyl-2-thioxopyridin-4-carboxylate

: 22303-36-2
N-(4-methoxyphenyl)-2-chloroacetamide

: 723745-22-0
ethyl 3-amino-2-{[(4-methoxyphenyl)amino]carbonyl}-4-(4-methoxyphenyl)-6-methylthieno[2,3-b]pyridine-5-carboxylate

Guidance literature:: With sodium ethanolate; In ethanol; for 4h; Heating;
DOI:10.1080/10426500500272152

Reference yield:

: 97651-29-1
ethyl 3-cyano-1,2-dihydro-4-p-methoxyphenyl-6-methyl-2-thioxopyridin-4-carboxylate

: 723745-22-0
ethyl 3-amino-2-{[(4-methoxyphenyl)amino]carbonyl}-4-(4-methoxyphenyl)-6-methylthieno[2,3-b]pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / sodium acetate trihydrate / ethanol / 2 h / Heating

2: 95 percent / sodium ethoxide / ethanol / 0.08 h / Heating

With sodium ethanolate; sodium acetate; In ethanol; 2: Thorpe-Ziegler cyclization;
DOI:10.1080/10426500601096369