1H-Isoindole-1,3(2H)-dione, 2-[[(5S)-3-(3-fluoro-4-iodophenyl)-2-oxo-5-oxazolidinyl]Methyl]-

Base Information

Chemical Name:1H-Isoindole-1,3(2H)-dione, 2-[[(5S)-3-(3-fluoro-4-iodophenyl)-2-oxo-5-oxazolidinyl]Methyl]-
CAS No.:724793-80-0
Molecular Formula:C18H12FIN2O4
Molecular Weight:466.207
Hs Code.:
Mol file:724793-80-0.mol

Synonyms:(5S)-2-[3-(3-fluoro-4-iodo-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-isoindole-1,3-dione;(S)-1-ETHYL-5-METHYLPIPERAZIN-2-ONE;

Suppliers and Price of 1H-Isoindole-1,3(2H)-dione, 2-[[(5S)-3-(3-fluoro-4-iodophenyl)-2-oxo-5-oxazolidinyl]Methyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of 1H-Isoindole-1,3(2H)-dione, 2-[[(5S)-3-(3-fluoro-4-iodophenyl)-2-oxo-5-oxazolidinyl]Methyl]-

Chemical Property:

PSA：66.92000
LogP:3.05460

Purity/Quality:: NLT 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1H-Isoindole-1,3(2H)-dione, 2-[[(5S)-3-(3-fluoro-4-iodophenyl)-2-oxo-5-oxazolidinyl]Methyl]-

There total 5 articles about 1H-Isoindole-1,3(2H)-dione, 2-[[(5S)-3-(3-fluoro-4-iodophenyl)-2-oxo-5-oxazolidinyl]Methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 501939-82-8
(5R)-methanesulfonic acid 3-(3-fluoro-4-iodophenyl)-2-oxo-oxazolidin-5-ylmethyl ester

: 1074-82-4
potassium phtalimide

: 724793-80-0
(S)-2-((3-(3-fluoro-4-iodophenyl)-2-oxooxazolidin-5-yl)methyl)isoindoline-1,3-dione

Guidance literature:: In N,N-dimethyl-formamide; at 70 ℃; for 4h;
DOI:10.1016/j.bmcl.2017.10.018

Reference yield:

: 372-19-0
meta-fluoroaniline

: 724793-80-0
(S)-2-((3-(3-fluoro-4-iodophenyl)-2-oxooxazolidin-5-yl)methyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran / 0.08 h / 0 °C

1.2: 3 h / 0 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.33 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: trifluoroacetic acid; N-iodo-succinimide / 2 h / 20 °C

4.1: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Inert atmosphere

5.1: N,N-dimethyl-formamide / 4 h / 70 °C

With N-iodo-succinimide; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2017.10.018

Reference yield:

: 149524-47-0
N-(carbobenzyloxy)-3-fluoroaniline

: 724793-80-0
(S)-2-((3-(3-fluoro-4-iodophenyl)-2-oxooxazolidin-5-yl)methyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.33 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: trifluoroacetic acid; N-iodo-succinimide / 2 h / 20 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 - 5 °C / Inert atmosphere

4.1: N,N-dimethyl-formamide / 4 h / 70 °C

With N-iodo-succinimide; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2017.10.018