4-Quinolinecarboxylic acid, 2-((3-methoxyphenyl)amino)-, 2-(4-morpholinylacetyl)hydrazide

Base Information

Chemical Name:4-Quinolinecarboxylic acid, 2-((3-methoxyphenyl)amino)-, 2-(4-morpholinylacetyl)hydrazide
CAS No.:134721-84-9
Molecular Formula:C₂₃H₂₅N₅O₄
Molecular Weight:435.483
Hs Code.:
DSSTox Substance ID:DTXSID60158915
Wikidata:Q83027214
Mol file:134721-84-9.mol

Synonyms:BRN 4829495;4-Quinolinecarboxylic acid, 2-((3-methoxyphenyl)amino)-, 2-(4-morpholinylacetyl)hydrazide;134721-84-9;2-((3-Methoxyphenyl)amino)-4-quinolinecarboxylic acid 2-(4-morpholinylacetyl)hydrazide;DTXSID60158915;LS-141660

Suppliers and Price of 4-Quinolinecarboxylic acid, 2-((3-methoxyphenyl)amino)-, 2-(4-morpholinylacetyl)hydrazide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-Quinolinecarboxylic acid, 2-((3-methoxyphenyl)amino)-, 2-(4-morpholinylacetyl)hydrazide

Chemical Property:

Boiling Point:704.6°Cat760mmHg
Flash Point:379.9°C
Density:1.303g/cm³
XLogP3:2.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:435.19065430
Heavy Atom Count:32
Complexity:630

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC(=C1)NC2=NC3=CC=CC=C3C(=C2)C(=O)NNC(=O)CN4CCOCC4

Technology Process of 4-Quinolinecarboxylic acid, 2-((3-methoxyphenyl)amino)-, 2-(4-morpholinylacetyl)hydrazide

There total 3 articles about 4-Quinolinecarboxylic acid, 2-((3-methoxyphenyl)amino)-, 2-(4-morpholinylacetyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 110-91-8,99108-56-2
morpholine

: 134721-77-0
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid N'-(2-chloro-acetyl)-hydrazide

: 134721-84-9
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid N'-(2-morpholin-4-yl-acetyl)-hydrazide

Guidance literature:: In 1,4-dioxane; for 1h; Heating;
DOI:10.1007/BF00772014

Reference yield:

: 134721-71-4
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid hydrazide

: 134721-84-9
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid N'-(2-morpholin-4-yl-acetyl)-hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / NaOAc, acetic acid / 24 h / Ambient temperature

2: 61 percent / dioxane / 1 h / Heating

With sodium acetate; acetic acid; In 1,4-dioxane;
DOI:10.1007/BF00772014

Reference yield:

: 134721-65-6
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid ethyl ester

: 134721-84-9
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid N'-(2-morpholin-4-yl-acetyl)-hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / hydrazine hydrate / ethanol / 2 h / Heating

2: 88 percent / NaOAc, acetic acid / 24 h / Ambient temperature

3: 61 percent / dioxane / 1 h / Heating

With sodium acetate; hydrazine hydrate; acetic acid; In 1,4-dioxane; ethanol;
DOI:10.1007/BF00772014