4-Quinolinecarboxylic acid, 2-((3-methoxyphenyl)amino)-, 2-(chloroacetyl)hydrazide

Base Information

Chemical Name:4-Quinolinecarboxylic acid, 2-((3-methoxyphenyl)amino)-, 2-(chloroacetyl)hydrazide
CAS No.:134721-77-0
Molecular Formula:C₁₉H₁₇ClN₄O₃
Molecular Weight:384.822
Hs Code.:
DSSTox Substance ID:DTXSID20158911
Nikkaji Number:J419.123D
Wikidata:Q83027209

Synonyms:BRN 4825263;4-Quinolinecarboxylic acid, 2-((3-methoxyphenyl)amino)-, 2-(chloroacetyl)hydrazide;2-((3-Methoxyphenyl)amino)-4-quinolinecarboxylic acid 2-(chloroacetyl)hydrazide;134721-77-0;C19H17ClN4O3;DTXSID20158911;LS-141657;N'-Chloroacetyl-2-(3-methoxyphenylamino)quinoline-4-carbohydrazide

Suppliers and Price of 4-Quinolinecarboxylic acid, 2-((3-methoxyphenyl)amino)-, 2-(chloroacetyl)hydrazide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 4-Quinolinecarboxylic acid, 2-((3-methoxyphenyl)amino)-, 2-(chloroacetyl)hydrazide

Chemical Property:

Boiling Point:659.9°Cat760mmHg
Flash Point:352.9°C
Density:1.369g/cm³
XLogP3:3.4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:384.0989181
Heavy Atom Count:27
Complexity:521

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=CC(=C1)NC2=NC3=CC=CC=C3C(=C2)C(=O)NNC(=O)CCl

Technology Process of 4-Quinolinecarboxylic acid, 2-((3-methoxyphenyl)amino)-, 2-(chloroacetyl)hydrazide

There total 2 articles about 4-Quinolinecarboxylic acid, 2-((3-methoxyphenyl)amino)-, 2-(chloroacetyl)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 134721-71-4
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid hydrazide

: 79-04-9
chloroacetyl chloride

: 134721-77-0
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid N'-(2-chloro-acetyl)-hydrazide

Guidance literature:: With sodium acetate; acetic acid; for 24h; Ambient temperature;
DOI:10.1007/BF00772014

Reference yield:

: 134721-65-6
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid ethyl ester

: 134721-77-0
2-(3-Methoxy-phenylamino)-quinoline-4-carboxylic acid N'-(2-chloro-acetyl)-hydrazide

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / hydrazine hydrate / ethanol / 2 h / Heating

2: 88 percent / NaOAc, acetic acid / 24 h / Ambient temperature

With sodium acetate; hydrazine hydrate; acetic acid; In ethanol;
DOI:10.1007/BF00772014