Methyl-ethyl-beta-chloroethylamine hydrochloride

Base Information

• Chemical Name: Methyl-ethyl-beta-chloroethylamine hydrochloride
• CAS No.: 4535-88-0
• Molecular Formula: C5H13Cl2N
• Molecular Weight: 158.0694
• Hs Code.: 2921199090
• European Community (EC) Number: 842-781-8
• Mol file: 4535-88-0.mol

Synonyms:Methyl-ethyl-beta-chloroethylamine hydrochloride;2-Chloro-N-methyldiethylamine hydrochloride;DIETHYLAMINE, 2-CHLORO-N-METHYL-, HYDROCHLORIDE;2-chloroethyl-ethyl-methylazanium;chloride;4535-88-0;LS-61834;Ethanamine, 2-chloro-N-ethyl-N-methyl-, hydrochloride

Chemical Property of Methyl-ethyl-beta-chloroethylamine hydrochloride

Chemical Property:

• Vapor Pressure: 64.8mmHg at 25°C
• Melting Point: 115-118°C
• Boiling Point: 87°Cat760mmHg
• Flash Point: 6.4°C
• PSA: 3.24000
• Density: g/cm³
• LogP: 1.97890
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 157.0425048
• Heavy Atom Count: 8
• Complexity: 39.1

Purity/Quality:

99% ^*data from raw suppliers

Methyl-ethyl-beta-chloroethylaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC[NH+](C)CCCl.[Cl-]
• Uses: 2-Chloro-N-methylethanamine is an aminoalkoxyimino derivative used in the preparation of amino derivatives of B-homoandrostanes and B-heteroandrostanes for the treatment of cardiovascular disorders.

Technology Process of Methyl-ethyl-beta-chloroethylamine hydrochloride

There total 1 articles about Methyl-ethyl-beta-chloroethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

2-(N-ethyl-N-methylamino)ethanol (2893-43-8) → 2-chloro-N-ethyl-N-methylethanamine hydrochloride (4535-88-0)

Guidance literature:

With thionyl chloride; at 50 ℃; for 1h;

Reference yield: 80.0%

2-chloro-N-ethyl-N-methylethanamine hydrochloride (4535-88-0) + (+/-)-cis-8-chloro-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one (96125-60-9) → (2R,3R)-8-Chloro-5-[2-(ethyl-methyl-amino)-ethyl]-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one (105487-94-3,96125-34-7)

Guidance literature:

With potassium carbonate; In acetone; for 17h; Heating;

DOI:10.1021/jm00106a032

Reference yield: 74.0%

2,6-diisopropylbenzenamine (24544-04-5) + 2-chloro-N-ethyl-N-methylethanamine hydrochloride (4535-88-0) → N-(2,6-diisopropylphenyl)-N′-ethyl-N′-methylethane-1,2-diamine

Guidance literature:

at 30 ℃; for 72h;

DOI:10.1002/ejic.201601355

upstream raw materials:

2-(N-ethyl-N-methylamino)ethanol

Downstream raw materials:

(2R,3R)-8-Chloro-5-[2-(ethyl-methyl-amino)-ethyl]-3-hydroxy-2-(4-methoxy-phenyl)-2,3-dihydro-5H-benzo[b][1,4]thiazepin-4-one