Cyclohexanone, O-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]oxime

Base Information

• Chemical Name: Cyclohexanone, O-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]oxime
• CAS No.: 73313-19-6
• Molecular Formula: C₁₃H₂₆N₂O₂
• Molecular Weight: 242.362
• Mol file: 73313-19-6.mol

Synonyms:

Chemical Property of Cyclohexanone, O-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanone, O-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]oxime

There total 3 articles about Cyclohexanone, O-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl]oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cyclohexanone O-oxiranylmethyl-oxime (23753-42-6) + tert-butylamine (75-64-9) → Cyclohexanone O-(3-tert-butylamino-2-hydroxy-propyl)-oxime (73313-19-6)

Guidance literature:

In ethanol; for 12h; Yield given; Heating;

DOI:10.1021/jm00180a007

Reference yield:

cyclohexanone-oxime (100-64-1) → Cyclohexanone O-(3-tert-butylamino-2-hydroxy-propyl)-oxime (73313-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) MeONa / 1.) methanol, reflux, 1 h, 2.) DMF, RT, 1 h

2: benzene / 12 h / 90 °C

With sodium methylate; In benzene;

DOI:10.1021/jm00380a001

Reference yield:

cyclohexanone-oxime (100-64-1) → Cyclohexanone O-(3-tert-butylamino-2-hydroxy-propyl)-oxime (73313-19-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) sodium methoxide / 1.) MeOH, reflux, 1 h, 2.) DMF, 1 h

2: ethanol / 12 h / Heating

With sodium methylate; In ethanol;

DOI:10.1021/jm00180a007

upstream raw materials:

Cyclohexanone O-oxiranylmethyl-oxime

tert-butylamine

cyclohexanone-oxime

Refernces

• 1、 Leclerc, Gerard,Bieth, Nicole,Schwartz, Jean. "Synthesis and β-Adrenergic Blocking Activity of New Aliphatic Oxime Ethers". . p. 620 - 624. Retrieved 2007/10/02.