Technology Process of Amastatin
There total 12 articles about Amastatin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: DCC, HOBt, Et3N
2: TFA
3: DCC, HOBt, Et3N
4: TFA
5: DCC, HOBt, Et3N
6: H2 / Pd-C
With
hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal;
DOI:10.1271/bbb1961.46.1865
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NaHSO3 / 1.) 5 deg C, overnight, 2.) ethyl acetate, water, room temp., 4 h
2: 90 percent / concentrated HCl / dioxane / 12 h / Heating
3: 73 percent / triethylamine / H2O; dioxane / 25 °C
4: 1.) hydrochloric acid, 2.) triethylamine, DCC, HOBt / 1.) dioxane, 30 min, 25 deg C 2.) methylene chloride
5: 1.) TFA, 2.) H2, Pd/C / 1.) room temperature, 30 min 2.) methanol, 24 h
With
hydrogenchloride; palladium on activated charcoal; hydrogen; benzotriazol-1-ol; sodium hydrogensulfite; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
1,4-dioxane; water;
DOI:10.1021/jo01300a004
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / concentrated HCl / dioxane / 12 h / Heating
2: 73 percent / triethylamine / H2O; dioxane / 25 °C
3: 1.) hydrochloric acid, 2.) triethylamine, DCC, HOBt / 1.) dioxane, 30 min, 25 deg C 2.) methylene chloride
4: 1.) TFA, 2.) H2, Pd/C / 1.) room temperature, 30 min 2.) methanol, 24 h
With
hydrogenchloride; palladium on activated charcoal; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;
In
1,4-dioxane; water;
DOI:10.1021/jo01300a004
