N-(TERT-BUTOXYCARBONYL)-L-VALYL-L-ASPARTIC ACID DIBENZYL ESTER

Base Information

• Chemical Name: N-(TERT-BUTOXYCARBONYL)-L-VALYL-L-ASPARTIC ACID DIBENZYL ESTER
• CAS No.: 70853-19-9
• Molecular Formula: C28H36 N2 O7
• Molecular Weight: 512.603
• Mol file: 70853-19-9.mol

Synonyms:NSC 336363

Chemical Property of N-(TERT-BUTOXYCARBONYL)-L-VALYL-L-ASPARTIC ACID DIBENZYL ESTER

Chemical Property:

• Vapor Pressure: 7.03E-18mmHg at 25°C
• Boiling Point: 671.2°Cat760mmHg
• Flash Point: 359.7°C
• PSA: 120.03000
• Density: 1.163g/cm³
• LogP: 4.67920

Purity/Quality:

N-(TERT-BUTOXYCARBONYL)-L-VALYL-L-ASPARTIC ACID DIBENZYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(TERT-BUTOXYCARBONYL)-L-VALYL-L-ASPARTIC ACID DIBENZYL ESTER

There total 2 articles about N-(TERT-BUTOXYCARBONYL)-L-VALYL-L-ASPARTIC ACID DIBENZYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

t-Boc-L-valine (13734-41-3) + dibenzyl L-aspartate toluene-4-sulphonate (2886-33-1) → Boc-Val-Asp(OBzl)-OBzl (70853-19-9)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 5 ℃;

DOI:10.1021/jo01300a004

Reference yield:

t-Boc-L-valine (13734-41-3) + dibenzyl L-aspartate (2791-79-9) → Boc-Val-Asp(OBzl)-OBzl (70853-19-9)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide;

DOI:10.1271/bbb1961.46.1865

Reference yield: 100.0%

Boc-Val-Asp(OBzl)-OBzl (70853-19-9) + trifluoroacetic acid (76-05-1) → L-valyl-L-aspartic acid dibenzyl ester TFA salt (70853-21-3)

Guidance literature:

In dichloromethane; at 25 ℃; for 0.75h;

DOI:10.1021/jo102592f

upstream raw materials:

t-Boc-L-valine

dibenzyl L-aspartate

dibenzyl L-aspartate toluene-4-sulphonate

Downstream raw materials:

<(tert-Butyloxy)carbonyl>-L-valyl-L-valyl-L-aspartic Acid Dibenzyl Ester

Val-Asp(OBzl)-OBzl

(2R,3R)-(3-Amino-2-hydroxy-5-methylhexanoyl)-L-valyl-L-valyl-L-aspartic Acid

amastatin