3-Amino-3-azabicyclo[3.3.0]octane hydrochloride

Base Information

• Chemical Name: 3-Amino-3-azabicyclo[3.3.0]octane hydrochloride
• CAS No.: 58108-05-7
• Molecular Formula: C7H14N2^.HCl
• Molecular Weight: 162.662
• Hs Code.: 2933990090
• Mol file: 58108-05-7.mol

Synonyms:Cyclopenta[c]pyrrol-2(1H)-amine,hexahydro-, monohydrochloride (9CI);2(1H)-Aminohexahydrocyclopenta[c]pyrrolehydrochloride;N-Amino-3-azabicyclo[3.3.0]octane hydrochloride;

Chemical Property of 3-Amino-3-azabicyclo[3.3.0]octane hydrochloride

Chemical Property:

• Appearance/Colour: light yellow brown powder
• Melting Point: 170-174 °C(lit.)
• Boiling Point: 229.9 °C at 760 mmHg
• Flash Point: 92.9 °C
• PSA: 29.26000
• LogP: 2.03220
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly),Water (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

3-Amino-3-azabicyclo[3.3.0]octane hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3-Amino-3-azabicyclo[3,3,0]octane Hydrochloride is used as a reactant in the synthesis of cannabinoid receptor antagonists.

Technology Process of 3-Amino-3-azabicyclo[3.3.0]octane hydrochloride

There total 7 articles about 3-Amino-3-azabicyclo[3.3.0]octane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-amino-aza-3-bicyclo<3.3.0>octane (54528-00-6) → 3-azabicyclo<3.3.0>oct-3-yl-amine monohydrochloride (58108-05-7)

Guidance literature:

With hydrogenchloride;

Reference yield: 81.3%

N-amino-1,2-cyclopentanedicarboximide (1050666-51-7) → 3-azabicyclo<3.3.0>oct-3-yl-amine monohydrochloride (58108-05-7)

Guidance literature:

N-amino-1,2-cyclopentanedicarboximide; With aluminum (III) chloride; In tetrahydrofuran; at 45 ℃; for 0.333333h; Large scale;

With sodium tetrahydroborate; In tetrahydrofuran; for 6h; Reflux; Large scale;

With hydrogenchloride; In tetrahydrofuran; pH=3; Solvent; Temperature; Large scale;

Reference yield:

cis-cyclopentane-1,2-dimethanol → 3-azabicyclo<3.3.0>oct-3-yl-amine monohydrochloride (58108-05-7)

Guidance literature:

With hydrogenchloride; hydrazine hydrochloride; In water; at 140 ℃; for 5h; under 1672.11 - 4256.29 Torr; Autoclave;

upstream raw materials:

gliclazide

N-amino-1,2-cyclopentanedicarboximide

N-amino-aza-3-bicyclo<3.3.0>octane

Downstream raw materials:

gliclazide

phenyl hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamate

Refernces

• 1、 -. "Method for preparing N-amino-3-aza-bicyclo [3, 3, 0] octane hydrochloride". Paragraph 0030-0032. . Retrieved 2018/10/19.
• 2、 Kobayashi,Igaki,Kimura,Sakoguchi,Shimosawa,Matsuoka. "Influence of blood proteins on biomedical analysis. IX. Protective effects of human serum proteins on anion-induced degradation of gliclazide". . p. 2957 - 2962. Retrieved 2007/10/02.