tert-Butyl dihydroxyacetate

Base Information

Chemical Name:tert-Butyl dihydroxyacetate
CAS No.:73633-07-5
Molecular Formula:C6H12O4
Molecular Weight:148.159
Hs Code.:
DSSTox Substance ID:DTXSID20552990
Wikidata:Q82433445

Synonyms:73633-07-5;tert-Butyl dihydroxyacetate;TERT-BUTYL 2,2-DIHYDROXYACETATE;SCHEMBL9508031;DTXSID20552990;TERT-BUTYL2,2-DIHYDROXYACETATE

Suppliers and Price of tert-Butyl dihydroxyacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of tert-Butyl dihydroxyacetate

Chemical Property:

PSA：66.76000
LogP:-0.36120
XLogP3:-0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:148.07355886
Heavy Atom Count:10
Complexity:122

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)C(O)O

Technology Process of tert-Butyl dihydroxyacetate

There total 2 articles about tert-Butyl dihydroxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 7633-32-1
tert-butyl glyoxylate

: 73633-07-5
t-butyl α,α-dihydroxyacetate

Guidance literature:: With 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide; In tetrahydrofuran; water; tert-butyl alcohol; at 40 ℃; for 5h; Inert atmosphere;
DOI:10.1002/anie.200804883

Reference yield:

: 7633-38-7
di-tert-butyl fumarate

: 7633-32-1
tert-butyl glyoxylate

: 73633-07-5
t-butyl α,α-dihydroxyacetate

Guidance literature:: di-tert-butyl fumarate; With ozone; In dichloromethane; at -78 ℃; for 0.5h;

With dimethylsulfide; In dichloromethane; at -78 - 20 ℃; for 2h; Title compound not separated from byproducts;
DOI:10.1039/b402764g

Reference yield:

: 73633-07-5
t-butyl α,α-dihydroxyacetate

: (R)-3-[(2R,3R)-1-(tert-Butoxycarbonyl-chloro-methyl)-2-(2-methyl-acryloylsulfanyl)-4-oxo-azetidin-3-yl]-2,2-dimethyl-4-oxo-5-phenyl-imidazolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 573 mg / molecular sieves 4A / dimethylformamide; toluene / 3 h / Ambient temperature

2: 495 mg / SOCl₂, polymeric base / dioxane / 3 h / Ambient temperature

With thionyl chloride; 4 A molecular sieve; polymeric base; In 1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.19800630119