Methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate

Base Information

• Chemical Name: Methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate
• CAS No.: 736989-93-8
• Molecular Formula: C18H21BO4
• Molecular Weight: 312.173
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID10682235
• Wikidata: Q82606542
• Mol file: 736989-93-8.mol

Synonyms:736989-93-8;Methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate;methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalene-2-carboxylate;6-(Methoxycarbonyl)naphthalene-2-boronic acid pinacol ester;YSZC599;SCHEMBL1623079;DTXSID10682235;WEDOOEMXFXWHAU-UHFFFAOYSA-N;(6-(METHOXYCARBONYL)NAPHTHALEN-2-YL)BORONIC ACID PINACOL ESTER;Methyl6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate;MFCD18783177;AKOS016000988;AS-2792;CS-0096050;FT-0740466;EN300-7384339;A909725;Z3235021742;Methyl 6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2-naphthoate;methyl 6-(tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalene-2-carboxylate

Chemical Property of Methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate

Chemical Property:

• Boiling Point: 441.2±18.0 °C(Predicted)
• PSA: 44.76000
• Density: 1.13±0.1 g/cm3(Predicted)
• LogP: 2.92560
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 312.1532893
• Heavy Atom Count: 23
• Complexity: 446

Purity/Quality:

97% ^*data from raw suppliers

6-(Methoxycarbonyl)naphthalene-2-boronicacidpinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC3=C(C=C2)C=C(C=C3)C(=O)OC

Technology Process of Methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate

There total 3 articles about Methyl 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl 6-bromo-2-naphthoate (33626-98-1) + bis(pinacol)diborane (73183-34-3) → 6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-naphthalene-2-carboxylic acid methyl ester (736989-93-8)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In dimethyl sulfoxide; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1039/c2cc31792c

Reference yield: 70.0%

→ 6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-naphthalene-2-carboxylic acid methyl ester (736989-93-8)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; at 80 ℃; for 4h; Inert atmosphere;

Reference yield:

6-bromo-2-naphthoic acid (5773-80-8) → 6-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-naphthalene-2-carboxylic acid methyl ester (736989-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / Reflux

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; potassium acetate; In 1,4-dioxane;

upstream raw materials:

methyl 6-bromo-2-naphthoate

bis(pinacol)diborane

6-bromo-2-naphthoic acid

Downstream raw materials:

methyl 6-[4-[2-[(tert-butoxycarbonyl)[(2R)-2-(3-chlorophenyl)-2-hydroxy-ethyl]amino]ethyl]phenyl]-2-naphthoate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 736989-93-8 Methyl 6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-naphthoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send