6-Phthalazinecarboxylic acid, 3,4-dihydro-5,7-dimethyl-3-(4-nitrophenyl)-4-oxo-, ethyl ester

Base Information

Chemical Name:6-Phthalazinecarboxylic acid, 3,4-dihydro-5,7-dimethyl-3-(4-nitrophenyl)-4-oxo-, ethyl ester
CAS No.:73731-49-4
Molecular Formula:C19H17N3O5
Molecular Weight:367.361
Hs Code.:

Synonyms:

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Chemical Property of 6-Phthalazinecarboxylic acid, 3,4-dihydro-5,7-dimethyl-3-(4-nitrophenyl)-4-oxo-, ethyl ester

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Technology Process of 6-Phthalazinecarboxylic acid, 3,4-dihydro-5,7-dimethyl-3-(4-nitrophenyl)-4-oxo-, ethyl ester

There total 9 articles about 6-Phthalazinecarboxylic acid, 3,4-dihydro-5,7-dimethyl-3-(4-nitrophenyl)-4-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 75357-55-0
7-(ethoxycarbonyl)-6,8-dimethyl-2-phenyl-1(2H)-phthalazinone

: 73731-49-4
7-(ethoxycarbonyl)-6,8-dimethyl-2-(4-nitrophenyl)-1(2H)-phthalazinone

Guidance literature:: With sulfuric acid; potassium nitrate; at 0 ℃; for 5h;
DOI:10.1021/jm00376a013

Reference yield:

: 56611-62-2
3,5-dimethyl-4-ethoxycarbonyl-phthalic anhydride

: 73731-49-4
7-(ethoxycarbonyl)-6,8-dimethyl-2-(4-nitrophenyl)-1(2H)-phthalazinone

Guidance literature:: Multi-step reaction with 6 steps

1: LiAlH(OBu-t)3 / tetrahydrofuran / 3 h / Ambient temperature

2: 69.4 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 4 h / Heating

3: AcOH / 1 h / 70 - 80 °C

4: 1 N aq. KOH / Ambient temperature

5: 65 percent / ethanol / 3 h / Heating

6: 50 percent / 95percent H₂SO₄, KNO₃ / 5 h / 0 °C

With potassium hydroxide; N-Bromosuccinimide; Perbenzoic acid; sulfuric acid; acetic acid; lithium tri-t-butoxyaluminum hydride; potassium nitrate; In tetrahydrofuran; tetrachloromethane; ethanol;
DOI:10.1021/jm00376a013

Reference yield:

: 56863-79-7
4-ethoxycarbonyl-2-methoxycarbonyl-3,5-dimethylbenzoic acid

: 73731-49-4
7-(ethoxycarbonyl)-6,8-dimethyl-2-(4-nitrophenyl)-1(2H)-phthalazinone

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2: NaBH₄ / tetrahydrofuran; H₂O / 3 h / Ambient temperature

3: 69.4 percent / N-bromosuccinimide, benzoyl peroxide / CCl₄ / 4 h / Heating

4: AcOH / 1 h / 70 - 80 °C

5: 1 N aq. KOH / Ambient temperature

6: 65 percent / ethanol / 3 h / Heating

7: 50 percent / 95percent H₂SO₄, KNO₃ / 5 h / 0 °C

With potassium hydroxide; sodium tetrahydroborate; N-Bromosuccinimide; Perbenzoic acid; sulfuric acid; acetic acid; potassium nitrate; triethylamine; In tetrahydrofuran; tetrachloromethane; ethanol; water;
DOI:10.1021/jm00376a013