1-N-(pyridin-3-ylmethyl)benzene-1,2-diamine

Base Information

• Chemical Name: 1-N-(pyridin-3-ylmethyl)benzene-1,2-diamine
• CAS No.: 73933-53-6
• Molecular Formula: C12H13N3
• Molecular Weight: 199.255
• Mol file: 73933-53-6.mol

Synonyms:N-(3-pyridinylmethyl)-1,2-benzenediamine;3-(N-(2-aminophenyl)aminomethyl)pyridine;

Chemical Property of 1-N-(pyridin-3-ylmethyl)benzene-1,2-diamine

Chemical Property:

• PSA: 50.94000
• LogP: 2.93010

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-N-(pyridin-3-ylmethyl)benzene-1,2-diamine

There total 6 articles about 1-N-(pyridin-3-ylmethyl)benzene-1,2-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-Aminomethylpyridine (3731-52-0) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → N-pyridin-3-ylmethyl-benzene-1,2-diamine (73933-53-6)

Guidance literature:

3-Aminomethylpyridine; ortho-nitrofluorobenzene;

With hydrogen; nickel; at 50 ℃; for 4h; under 2250.23 Torr;

Reference yield: 62.0%

3-pyridinecarboxaldehyde (500-22-1) + tert–butyl (2–aminophenyl)carbamate (146651-75-4) → N-pyridin-3-ylmethyl-benzene-1,2-diamine (73933-53-6)

Guidance literature:

3-pyridinecarboxaldehyde; tert–butyl (2–aminophenyl)carbamate; With acetic acid; In methanol; for 12h; Reflux; Inert atmosphere;

With sodium tetrahydroborate; In methanol; at 20 ℃; for 12h; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1002/chem.201402502

Reference yield:

N-(pyridin-3-ylmethyl)-2-nitroaniline (73933-52-5) → N-pyridin-3-ylmethyl-benzene-1,2-diamine (73933-53-6)

Guidance literature:

nickel; In methanol;

upstream raw materials:

3-Aminomethylpyridine

ortho-nitrofluorobenzene

N-(pyridin-3-ylmethyl)-2-nitroaniline

3-pyridinecarboxaldehyde

Downstream raw materials:

4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-carboxylic acid ((R)-2-(4-amino-3,5-dibromo-phenyl)-1-{2-[(pyridin-3-ylmethyl)-amino]-phenylcarbamoyl}-ethyl)-amide

4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-carboxylic acid [2-(3,4-dibromo-phenyl)-1-(1-pyridin-3-ylmethyl-1H-benzimidazol-2-yl)-ethyl]-amide

4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-carboxylic acid [2-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-1-(1-pyridin-3-ylmethyl-1H-benzimidazol-2-yl)-ethyl]-amide

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