5-Ethyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-ylamine

Base Information

• Chemical Name: 5-Ethyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-ylamine
• CAS No.: 17899-49-9
• Molecular Formula: C8H13 N3 S
• Molecular Weight: 183.277
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID70366488
• Wikidata: Q82151721
• ChEMBL ID: CHEMBL1414890
• Mol file: 17899-49-9.mol

Synonyms:17899-49-9;5-Ethyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-ylamine;5-ethyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridin-2-amine;5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-amine;5-ethyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-2-amine;Oprea1_061665;MLS001005691;SCHEMBL3590422;CHEMBL1414890;DTXSID70366488;MSKNCRMLUUGTDB-UHFFFAOYSA-N;HMS2733M19;AKOS000122182;PD158772;SMR000348902;EN300-02413;VU0317793-3;J-517473;Z56970974;F2145-0303;5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-ylamine

Chemical Property of 5-Ethyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-ylamine

Chemical Property:

• Vapor Pressure: 0.000205mmHg at 25°C
• Boiling Point: 327.2°Cat760mmHg
• Flash Point: 151.7°C
• PSA: 70.39000
• Density: 1.222g/cm³
• LogP: 1.62240
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 183.08301860
• Heavy Atom Count: 12
• Complexity: 164

Purity/Quality:

98%Min ^*data from raw suppliers

5-ethyl-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1CCC2=C(C1)SC(=N2)N

Technology Process of 5-Ethyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-ylamine

There total 2 articles about 5-Ethyl-4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

N-ethyl-4-piperidone (3612-18-8) + CYANAMID (420-04-2) → 2-amino-5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (17899-49-9)

Guidance literature:

N-ethyl-4-piperidone; With pyrrolidine; In isopropyl alcohol; at 55 ℃; for 2h;

CYANAMID; With sulfur; In isopropyl alcohol; at 0 - 20 ℃; for 6h;

DOI:10.1016/j.ejmech.2017.07.051

Reference yield:

→ 2-amino-5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (17899-49-9)

Guidance literature:

entspr.3-Brom-piperidon,Thioharnstoff;

Reference yield: 36.0%

3-((1-methoxypropan-2-yl)oxy)-5-(4-(methylsulfonyl)phenoxy)benzoic acid + 2-amino-5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (17899-49-9) → N-(5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-3-((1-methoxypropan-2-yl)oxy)-5-(4-(methylsulfonyl)phenoxy)benzamide

Guidance literature:

3-((1-methoxypropan-2-yl)oxy)-5-(4-(methylsulfonyl)phenoxy)benzoic acid; 2-amino-5-ethyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h; Inert atmosphere;

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2017.07.051

upstream raw materials:

N-ethyl-4-piperidone

CYANAMID

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