4-BROMOMETHYL-6,7-DIMETHOXYCOUMARIN

Base Information

• Chemical Name: 4-BROMOMETHYL-6,7-DIMETHOXYCOUMARIN
• CAS No.: 88404-25-5
• Molecular Formula: C12H11BrO4
• Molecular Weight: 299.12
• Hs Code.: 29322090
• Mol file: 88404-25-5.mol

Synonyms:4-Bromomethyl-6,7-dimethoxycoumarin;

Chemical Property of 4-BROMOMETHYL-6,7-DIMETHOXYCOUMARIN

Chemical Property:

• Appearance/Colour: light greenish-yellow powder
• Vapor Pressure: 3.65E-07mmHg at 25°C
• Melting Point: 212-216 °C(lit.)
• Refractive Index: 1.578
• Boiling Point: 417.1 °C at 760 mmHg
• Flash Point: 206 °C
• PSA: 48.67000
• Density: 1.515 g/cm³
• LogP: 2.70510
• Storage Temp.: Refrigerator
• Solubility.: Soluble in acetonitrile, dichloromethane, N,N-dimethylformamide, methanol
• Water Solubility.: Insoluble in water.

Purity/Quality:

98% ^*data from raw suppliers

4-(Bromomethyl)-6,7-dimethoxycoumarin ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,C
• Hazard Codes: Xn,C
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-Bromomethyl-6,7-dimethoxycoumarin is used as fluorescent labeling reagent for the reversed-phase HPLC separation and detection of carboxylic acids. It is also used as derivatization reagent: for quantitation of clofibric, bezafibric and fenofibric acids in liver by liquid chromatography, in determination of the concentration of tripeptide glutathione by matrix-assisted laser desorption ionization time-of-flight mass spectrometry and for determination of carboxylic acids in chromatographic detection. 4-Bromomethyl-6,7-dimethoxycoumarin was used as fluorescent labeling reagent for the reversed-phase HPLC separation and detection of carboxylic acids. It was also used as derivatization reagent:for quantitation of clofibric, bezafibric and fenofibric acids in liver by liquid chromatographyin determination of the concentration of tripeptide glutathione by matrix-assisted laser desorption ionization time-of-flight mass spectrometryfor determination of carboxylic acids in chromatographic detection

Technology Process of 4-BROMOMETHYL-6,7-DIMETHOXYCOUMARIN

There total 1 articles about 4-BROMOMETHYL-6,7-DIMETHOXYCOUMARIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 4-(bromomethyl)-6,7-dimethoxy-2-oxo-2H-chromene (88404-25-5)

Guidance literature:

Reference yield: 90.0%

4-(bromomethyl)-6,7-dimethoxy-2-oxo-2H-chromene (88404-25-5) → 6,7-dimethoxy-4-methylcoumarin (4281-40-7)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); poly(phenylsilane); In benzene-d6; at 82 - 85 ℃; for 3h; sealed;

DOI:10.1016/S0022-328X(97)00344-6

Reference yield: 81.0%

4-(bromomethyl)-6,7-dimethoxy-2-oxo-2H-chromene (88404-25-5) + 5-Hydroxy-N,N'-(6-methylpyridin-2-yl)benzene-1,3-dicarbonamide (335661-43-3) → 5-[(6,7-Dimethoxy-2-oxo-2H-chromen-4-yl)methyl]oxy-N,N'-(6-methyl-2-pyridinyl)benzene-1,3-dicarbonamide

Guidance literature:

With potassium carbonate; In acetonitrile; for 4h; Heating;

DOI:10.1002/1521-3765(20010202)7:3<664::AID-CHEM664>3.0.CO;2-E

Downstream raw materials:

6,7-dimethoxy-4-methylcoumarin

Refernces