5-Hydroxy-N,N'-(6-methylpyridin-2-yl)benzene-1,3-dicarbonamide

Base Information

• Chemical Name: 5-Hydroxy-N,N'-(6-methylpyridin-2-yl)benzene-1,3-dicarbonamide
• CAS No.: 335661-43-3
• Molecular Formula: C₂₀H₁₈N₄O₃
• Molecular Weight: 362.388
• Mol file: 335661-43-3.mol

Synonyms:5-Hydroxy-N,N'-(6-methylpyridin-2-yl)benzene-1,3-dicarbonamide

Chemical Property of 5-Hydroxy-N,N'-(6-methylpyridin-2-yl)benzene-1,3-dicarbonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Hydroxy-N,N'-(6-methylpyridin-2-yl)benzene-1,3-dicarbonamide

There total 2 articles about 5-Hydroxy-N,N'-(6-methylpyridin-2-yl)benzene-1,3-dicarbonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-Amino-6-methylpyridine (1824-81-3) + 5-Hydroxybenzene-1,3-dicarbonyl dichloride (61842-44-2) → 5-Hydroxy-N,N'-(6-methylpyridin-2-yl)benzene-1,3-dicarbonamide (335661-43-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1002/1521-3765(20010202)7:3<664::AID-CHEM664>3.0.CO;2-E

Reference yield:

5-Hydroxyisophthalic acid (618-83-7) → 5-Hydroxy-N,N'-(6-methylpyridin-2-yl)benzene-1,3-dicarbonamide (335661-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / tetrahydrofuran / 3 h / Heating

2: 75 percent / NEt₃ / tetrahydrofuran / 24 h / 20 °C

With thionyl chloride; triethylamine; In tetrahydrofuran;

DOI:10.1002/1521-3765(20010202)7:3<664::AID-CHEM664>3.0.CO;2-E

Reference yield: 81.0%

4-(bromomethyl)-6,7-dimethoxy-2-oxo-2H-chromene (88404-25-5) + 5-Hydroxy-N,N'-(6-methylpyridin-2-yl)benzene-1,3-dicarbonamide (335661-43-3) → 5-[(6,7-Dimethoxy-2-oxo-2H-chromen-4-yl)methyl]oxy-N,N'-(6-methyl-2-pyridinyl)benzene-1,3-dicarbonamide

Guidance literature:

With potassium carbonate; In acetonitrile; for 4h; Heating;

DOI:10.1002/1521-3765(20010202)7:3<664::AID-CHEM664>3.0.CO;2-E

upstream raw materials:

2-Amino-6-methylpyridine

5-Hydroxybenzene-1,3-dicarbonyl dichloride

5-Hydroxyisophthalic acid