Technology Process of 1H-Isoindole-1,3(2H)-dione,
2-[(1S,2S)-3,3,3-trifluoro-2-hydroxy-1-[(phenylmethoxy)methyl]propyl]-
There total 3 articles about 1H-Isoindole-1,3(2H)-dione,
2-[(1S,2S)-3,3,3-trifluoro-2-hydroxy-1-[(phenylmethoxy)methyl]propyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
potassium phtalimide; (3R,4S)-3-benzyloxymethyl-4-trifluoromethyl-2,2-dioxo-1,3,2-dioxathiolane;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 4h;
With
sulfuric acid;
In
tetrahydrofuran; water;
at 20 ℃;
DOI:10.1021/jo0497611
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 93 percent / (DHQ)PHAL; OsO4; K2CO3 / K3Fe(CN)6; MeSO2NH4 / 2-methyl-propan-2-ol; H2O / 48 h / 20 °C
2.1: SOCl2; Et3N
2.2: NaIO4; RuCl3
3.1: dimethylformamide / 4 h / 80 °C
3.2: 74 percent / H2SO4 / tetrahydrofuran; H2O / 20 °C
With
osmium(VIII) oxide; thionyl chloride; potassium carbonate; 4-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]-1-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]phthalazine; triethylamine;
MeSO2NH4; potassium hexacyanoferrate(III);
In
water; N,N-dimethyl-formamide; tert-butyl alcohol;
1.1: Sharpless asymmetric epoxidation;
DOI:10.1021/jo0497611
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: SOCl2; Et3N
1.2: NaIO4; RuCl3
2.1: dimethylformamide / 4 h / 80 °C
2.2: 74 percent / H2SO4 / tetrahydrofuran; H2O / 20 °C
With
thionyl chloride; triethylamine;
In
N,N-dimethyl-formamide;
DOI:10.1021/jo0497611
