3-methyl-2-phenylbut-2-enamide

Base Information

• Chemical Name: 3-methyl-2-phenylbut-2-enamide
• CAS No.: 7465-12-5
• Molecular Formula: C11H13 N O
• Molecular Weight: 175.227
• Mol file: 7465-12-5.mol

Synonyms:Crotonamide,3-methyl-2-phenyl- (6CI,7CI,8CI); NSC 400160; b,b-Dimethylatropamide

Chemical Property of 3-methyl-2-phenylbut-2-enamide

Chemical Property:

• Vapor Pressure: 3.93E-05mmHg at 25°C
• Boiling Point: 352.1°Cat760mmHg
• Flash Point: 166.7°C
• Density: 1.046g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-methyl-2-phenylbut-2-enamide

There total 2 articles about 3-methyl-2-phenylbut-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetonitrile (140-29-4) → 3-methyl-2-phenylbut-2-enamide (7465-12-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium; CaO; triethyl-benzyl-ammonium chloride

2: H₂SO₄; acetic acid

With sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; potassium; acetic acid; calcium oxide;

Reference yield:

β,β-dimethyl-α-phenylacrylonitrile (18670-23-0) → 3-methyl-2-phenylbut-2-enoic acid (4412-08-2) + 3-methyl-2-phenylbut-2-enamide (7465-12-5)

Guidance literature:

With sulfuric acid; acetic acid;

Reference yield: 82.0%

3-methyl-2-phenylbut-2-enamide (7465-12-5) → C11H13F2NO

Guidance literature:

With pyridinium polyhydrogenfluoride; dimethyl 2,2'-((2-iodo-5-(methoxycarbonyl)-1,3-phenylene)bis(oxy))diacetate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 12h; Sealed tube;

DOI:10.1021/jacs.6b02391

upstream raw materials:

β,β-dimethyl-α-phenylacrylonitrile

phenylacetonitrile