2H-Isoindole-2-acetic acid, 4,7-bis(bromomethyl)-1,3-dihydro-1,3-dioxo-, 2-[2-[[5-[2-(2-phenoxyethoxy)ethoxy]-1-naphthalenyl]oxy]ethoxy]ethyl ester

Base Information

Chemical Name:2H-Isoindole-2-acetic acid, 4,7-bis(bromomethyl)-1,3-dihydro-1,3-dioxo-, 2-[2-[[5-[2-(2-phenoxyethoxy)ethoxy]-1-naphthalenyl]oxy]ethoxy]ethyl ester
CAS No.:753006-60-9
Molecular Formula:C36H35Br2NO9
Molecular Weight:785.483
Hs Code.:

2H-Isoindole-2-acetic acid,
4,7-bis(bromomethyl)-1,3-dihydro-1,3-dioxo-,
2-[2-[[5-[2-(2-phenoxyethoxy)ethoxy]-1-naphthalenyl]oxy]ethoxy]ethyl
ester

Synonyms:

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Chemical Property of 2H-Isoindole-2-acetic acid, 4,7-bis(bromomethyl)-1,3-dihydro-1,3-dioxo-, 2-[2-[[5-[2-(2-phenoxyethoxy)ethoxy]-1-naphthalenyl]oxy]ethoxy]ethyl ester

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Technology Process of 2H-Isoindole-2-acetic acid, 4,7-bis(bromomethyl)-1,3-dihydro-1,3-dioxo-, 2-[2-[[5-[2-(2-phenoxyethoxy)ethoxy]-1-naphthalenyl]oxy]ethoxy]ethyl ester

There total 6 articles about 2H-Isoindole-2-acetic acid, 4,7-bis(bromomethyl)-1,3-dihydro-1,3-dioxo-, 2-[2-[[5-[2-(2-phenoxyethoxy)ethoxy]-1-naphthalenyl]oxy]ethoxy]ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 753006-59-6
(4,7-bis-bromomethyl-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetic acid

: 2-(2-{5-[2-(2-phenoxy-ethoxy)-ethoxy]-naphthalen-1-yloxy}-ethoxy)-ethanol

: 753006-60-9
(4,7-bis-bromomethyl-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetic acid 2-(2-{5-[2-(2-phenoxy-ethoxy)-ethoxy]-naphthalen-1-yloxy}-ethoxy)-ethyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1021/ja048164t

Reference yield:

: 15540-88-2
4,7-dimethylisoindoline-1,3-dione

: 753006-60-9
(4,7-bis-bromomethyl-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetic acid 2-(2-{5-[2-(2-phenoxy-ethoxy)-ethoxy]-naphthalen-1-yloxy}-ethoxy)-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / K₂CO₃ / acetonitrile / 3 h / Heating

2: 1.40 g / NBS; AIBN / CH₂Cl₂ / 4 h / Heating

3: 1.09 g / aq. HNO₃ / CH₂Cl₂ / 3 h / 20 °C

4: 77 percent / 1,3-dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 20 °C

With dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); nitric acid; potassium carbonate; dicyclohexyl-carbodiimide; In dichloromethane; acetonitrile;
DOI:10.1002/chem.200400614

Reference yield:

: 346701-87-9
2-{2-{5-[2-(2-hydroxyethoxy)ethoxy]naphthalene-1-yloxy}ethoxy}ethane tosylate

: 753006-60-9
(4,7-bis-bromomethyl-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-acetic acid 2-(2-{5-[2-(2-phenoxy-ethoxy)-ethoxy]-naphthalen-1-yloxy}-ethoxy)-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / K₂CO₃; LiBr; [18]crown-6 / acetonitrile / 24 h / Heating

2: 77 percent / 1,3-dicyclohexylcarbodiimide; 4-dimethylaminopyridine / CH₂Cl₂ / 20 °C

With dmap; 18-crown-6 ether; potassium carbonate; dicyclohexyl-carbodiimide; lithium bromide; In dichloromethane; acetonitrile;
DOI:10.1002/chem.200400614