3-(Cbz-aminomethyl)phenol

Base Information

• Chemical Name: 3-(Cbz-aminomethyl)phenol
• CAS No.: 75383-61-8
• Molecular Formula: C15H15NO3
• Molecular Weight: 257.28400
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID30553913
• Wikidata: Q82434640
• Mol file: 75383-61-8.mol

Synonyms:3-(CBZ-AMINOMETHYL)PHENOL;75383-61-8;benzyl 3-hydroxybenzylcarbamate;Benzyl (3-hydroxybenzyl)carbamate;BENZYL N-[(3-HYDROXYPHENYL)METHYL]CARBAMATE;MFCD14585006;AMY9004;DTXSID30553913;AKOS027256633;s10323;Benzyl [(3-hydroxyphenyl)methyl]carbamate;CS-11159;SY007184;CS-0354095;EN300-6253630

Chemical Property of 3-(Cbz-aminomethyl)phenol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 474.997oC at 760 mmHg
• Flash Point: 241.07oC
• PSA: 62.05000
• Density: 1.224g/cm3
• LogP: 3.02300
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 257.10519334
• Heavy Atom Count: 19
• Complexity: 277

Purity/Quality:

97% ^*data from raw suppliers

3-(Cbz-aminomethyl)phenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NCC2=CC(=CC=C2)O

Technology Process of 3-(Cbz-aminomethyl)phenol

There total 1 articles about 3-(Cbz-aminomethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-hydroxybenzylamine (73604-31-6) + benzyl chloroformate (501-53-1,94274-21-2) → m-N-carbobenzoxy-α-aminomethylphenol (75383-61-8)

Guidance literature:

Reference yield: 76.0%

m-N-carbobenzoxy-α-aminomethylphenol (75383-61-8) + acetyl chloride (75-36-5) → Acetic acid 3-(benzyloxycarbonylamino-methyl)-phenyl ester

Guidance literature:

With triethylamine; In tetrahydrofuran; for 0.75h; Ambient temperature;

Reference yield:

m-N-carbobenzoxy-α-aminomethylphenol (75383-61-8) + (R)-2-{(S)-2-tert-Butoxycarbonylamino-3-[3,5-dinitro-4-(toluene-4-sulfonyloxy)-phenyl]-propionylamino}-4-methyl-pentanoic acid methyl ester → (R)-2-((S)-3-{4-[4-(Benzyloxycarbonylamino-methyl)-phenoxy]-3,5-dinitro-phenyl}-2-tert-butoxycarbonylamino-propionylamino)-4-methyl-pentanoic acid methyl ester

Guidance literature:

In pyridine; at 90 ℃; Yield given;

DOI:10.1021/ja00214a075

upstream raw materials:

3-hydroxybenzylamine

benzyl chloroformate

Downstream raw materials:

m-acetoxybenzylamine p-toluenesulfonate