1-(4-Biphenylyl)-1-(4-fluorophenyl)-2-(imidazol-1-yl)-ethanol

Base Information

Chemical Name:1-(4-Biphenylyl)-1-(4-fluorophenyl)-2-(imidazol-1-yl)-ethanol
CAS No.:75459-14-2
Molecular Formula:C23H19FN2O
Molecular Weight:358.415
Hs Code.:
ChEMBL ID:CHEMBL106806
DSSTox Substance ID:DTXSID10875423
Nikkaji Number:J491.805C

Synonyms:75459-14-2;CHEMBL106806;SCHEMBL11187671;DTXSID10875423;BTOQYKKYPOUZGJ-UHFFFAOYSA-N;[1,1'-Biphenyl]-4-methanol, a-(4-fluorophenyl)-a;1-(4-biphenylyl)-1-(4-fluorophenyl)-2-(imidazol-1-yl)-ethanol

Suppliers and Price of 1-(4-Biphenylyl)-1-(4-fluorophenyl)-2-(imidazol-1-yl)-ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-Biphenylyl)-1-(4-fluorophenyl)-2-(imidazol-1-yl)-ethanol

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:358.14814140
Heavy Atom Count:27
Complexity:453

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CC=C(C=C2)C(CN3C=CN=C3)(C4=CC=C(C=C4)F)O

Technology Process of 1-(4-Biphenylyl)-1-(4-fluorophenyl)-2-(imidazol-1-yl)-ethanol

There total 4 articles about 1-(4-Biphenylyl)-1-(4-fluorophenyl)-2-(imidazol-1-yl)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 288-32-4
1H-imidazole

: 142657-57-6
1-(4-fluorophenyl)-1-(phenylphenyl)epoxyethane

: 75459-14-2
1-(4-fluorophenyl)-1-(4-phenylphenyl)-2-(1-imidazolyl)-1-ethanol

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 90 ℃; for 20h;
DOI:10.1021/jm00095a009

Reference yield:

: 288-32-4
1H-imidazole

: 1-(4-biphenylyl)-2-chloro-1-(4-fluorophenyl)-ethanol

: 75459-14-2
1-(4-fluorophenyl)-1-(4-phenylphenyl)-2-(1-imidazolyl)-1-ethanol

Guidance literature:: With sodium methylate; In N-methyl-acetamide; methanol; water;

Reference yield:

: 92-66-0
4-bromo-1,1'-biphenyl

: 75459-14-2
1-(4-fluorophenyl)-1-(4-phenylphenyl)-2-(1-imidazolyl)-1-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / n-butyllithium / tetrahydrofuran / -78 - 0 °C

2: 22 percent / t-BuOK / dimethylformamide / 20 h / 90 °C

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00095a009